Regulation of V(D)J Recombination by E-Protein Transcription Factors

  • Mary Elizabeth Jones
  • Yuan ZhuangEmail author
Part of the Advances in Experimental Medicine and Biology book series (volume 650)


Extensive study of the E-proteins E2A and HEB during lymphocyte development has revealed various functions for these bHLH transcription factors in regulating V(D)J recombination in both B- and T-cells. The study of E-proteins in mammals began with the identification of E2A by its ability to bind immunoglobulin heavy and light chain enhancers. Subsequent analysis has identified numerous roles for E2A and HEB at the immunoglobulin and T-cell receptor loci. E-protein targets also include the rag genes and other factors critical for recombination and for regulation of the developmental windows when cells undergo recombination. E-proteins appear to be master regulators that coordinate antigen receptor gene rearrangement and expression. This chapter focuses on how E-proteins regulate V(D)J recombination by activating transcription, initiating rearrangement and driving differentiation during B- and T-cell development.


Chromatin Accessibility Double Positive Transcriptional Enhancer Nonlymphoid Cell Surrogate Light Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Department of ImmunologyDuke University Medical CenterDurhamUSA

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