Bridging the Gap Between Experimental Animals and Humans in Osteosarcoma

  • Stephen J. Withrow
  • Chand Khanna
Part of the Cancer Treatment and Research book series (CTAR, volume 152)


Osteosarcoma has been reported in virtually all species of mammals (mouse, rat, rabbit, wolf, monkey, cat, dog, horse, ferret, cow, grizzly bear, camel, polar bear, and more), reptiles, fish, birds, and dinosaurs. The pet dog with osteosarcoma shares many similarities with the human condition, including histology, local and metastatic progression, and response to conventional treatment modalities.1 These similarities, coupled with the high prevalence of osteosarcoma in pet dogs, provide important opportunities to improve our understanding of osteosarcoma biology and therapy through the study of this naturally occurring model (Table 1)2.


Polar Bear Grizzly Bear Intact Immune System Canine Osteosarcoma Conventional Treatment Modality 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.College of Veterinary Medicine and Biomedical SciencesColorado State UniversityFt CollinsUSA
  2. 2.Comparative Oncology ProgramCenter for Cancer Research, National Cancer InstituteBethesdaUSA

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