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Changes in NK1 and Glutamate Receptors in Pain

  • Andrew J. Todd
Chapter

Abstract

The amino acid glutamate and the neuropeptide substance P are contained in many nociceptive primary afferents that terminate mainly in the superficial part of the dorsal horn. Both glutamate and substance P are released from the central terminals of nociceptive afferents following noxious stimulation. Glutamate acts on a variety of ionotropic and metabotropic receptors, while substance P acts on the neurokinin 1 receptor (NK1r), and both transmitters contribute to the processing of nociceptive information at the spinal level. Noxious stimulation of the hindpaw causes rapid (within minutes) internalisation of the NK1r, phosphorylation of the GluR1 subunit of the AMPA-type glutamate receptor and phosphorylation of the NR1 subunit of NMDA-type glutamate receptors. These plastic changes of SP and glutamate receptors that occur in acute and chronic pain states presumably contribute to sensitisation of dorsal horn neurons (central sensitization).

Keywords

Dorsal Horn Projection Neuron Dorsal Horn Neuron Spinal Nerve Ligation Noxious Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AMPA

α-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanic acid

CGRP

calcitonin gene related peptide

CFA

complete Freund’s adjuvant

CVLM

caudal ventrolateral medulla

DRG

dorsal root ganglion

LPb

lateral parabrachial area

LTP

long term potentiation

NK1r

neurokinin 1 receptor

NMDA

N-methyl-D-aspartate

PAG

periaqueductal grey

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Institute of Biomedical and Life SciencesUniversity of GlasgowGlasgowUK

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