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Nano- and Microparticles in Oral Delivery of Macromolecular Drugs

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Oral Delivery of Macromolecular Drugs

Abstract

Oral delivery systems are highly demanded and preferred over parenteral systems as they offer an ease of administration and therefore a high patient compliance. A promising strategy in order to improve the oral uptake of macromolecular drugs is the use of micro- and nanoparticulate delivery systems. The most widely used materials and techniques applied in the development of micro- and nanocarrier systems are described as well as the strategies to modify the particle’s surface in order to modulate their characteristics such as mucoadhesion, stability, protective effect, hydrophilicity or lipophilicity. Particles’ properties such as membrane-passing properties, permeation-enhancing properties, mucoadhesive properties, and protective properties are extensively discussed. Furthermore, evidence for the potential of such systems is provided with examples from recent in vivo studies.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Leopold-Franzens-University Innsbruck, Innrain 52, A 6020, Innsbruck, Austria

    Gioconda Millotti

  2. Institute of Pharmacy, University of Innsbruck, Innsbruck, Innsbruck, Austria

    Andreas Bernkop-Schnürch

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  1. Gioconda Millotti
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  2. Andreas Bernkop-Schnürch
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Correspondence to Gioconda Millotti .

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  1. Naturwissenschaftliche Fakultät, Universität Innsbruck, Innrain 52, Innsbruck, 6020, Austria

    Andreas Bernkop-Schnürch

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Millotti, G., Bernkop-Schnürch, A. (2009). Nano- and Microparticles in Oral Delivery of Macromolecular Drugs. In: Bernkop-Schnürch, A. (eds) Oral Delivery of Macromolecular Drugs. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0200-9_9

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