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Dendritic Cell Vaccines for Immunotherapy of Cancer: Challenges in Clinical Trials

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Targeted Cancer Immune Therapy

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Abstract

Dendritic cells (DCs) are potent activators of immunity. After years of careful laboratory research and painstaking work to define cell culture parameters that allow these cells to be expanded from precursors in vitro, DCs have been tested clinically. Over the last decade, they have demonstrated a clear ability to prime and boost immunity to foreign and self antigens in vitro and in vivo. Clinical trials have also indicated that DC-based vaccines can be effective in promoting clinically relevant antitumor immunity in a small percentage of cancer patients, but these important cells must be better understood for their full clinical potential to be realized.

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

    Lisa H. Butterfield

  2. Department of Surgery and Immunology, Research Pavilion, Rm 1.32d, 5117 Centre Avenue, University of Pittsburgh, 15213, Pittsburgh, PA, USA

    Lisa H. Butterfield

Authors
  1. Lazar Vujanovic
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  2. Lisa H. Butterfield
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Corresponding author

Correspondence to Lisa H. Butterfield .

Editor information

Editors and Affiliations

  1. Sidney Kimmel Cancer Center, Altman Row 10835, San Diego, 92121, U.S.A.

    Joseph Lustgarten

  2. Health Sciences Center, Louisiana State University, Bolivar Street 533, New Orleans, 70112, U.S.A.

    Yan Cui

  3. School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, 70803, U.S.A.

    Shulin Li

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Vujanovic, L., Butterfield, L.H. (2009). Dendritic Cell Vaccines for Immunotherapy of Cancer: Challenges in Clinical Trials. In: Lustgarten, J., Cui, Y., Li, S. (eds) Targeted Cancer Immune Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0170-5_9

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