Targeting Toll-Like Receptor for the Induction of Immune and Antitumor Responses

  • Joseph Lustgarten
  • Dominique Hoelzinger
  • Maria Adelaida Duque
  • Shannon Smith
  • Noweeda Mirza


A very unique and important feature of TLR (toll-like receptor) agonists is their ability to modulate TLR on the cells of the innate immune system resulting in changes that will induce effective and efficient adaptive immune responses. Therefore, stimulation of TLR pathways through their respective ligands presents a potentially attractive approach to activate adaptive anticancer immune responses. In this chapter, we summarize the effect of targeting some of the TLR for the induction of antitumor responses. Although the use of TLR agonists as future vaccine adjuvants seems very promising, we also need to proceed with caution and long term studies will be critical in assessing the propensity of chronic therapy to trigger autoimmune conditions or promote tumor growth.


Natural Killer Cell Acute Myeloid Leukemia Basal Cell Carcinoma Adaptive Immune Response Acute Myeloid Leukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Imler, J., and Hoffmann, J. (2001) Trends Cell Biol 11, 304PubMedCrossRefGoogle Scholar
  2. 2.
    Heine, H., and Lien, E. (2003) Int Arch Allergy Immunol 130, 180PubMedCrossRefGoogle Scholar
  3. 3.
    Schijns, V. (2001) Crit Rev Immunol 21, 75PubMedGoogle Scholar
  4. 4.
    Barton, G., and Medzhitov, R. (2002) Curr Opin Immunol 14, 380PubMedCrossRefGoogle Scholar
  5. 5.
    Huang, Q., Liu, D., Majewski, P., Schulte, L., Korn, J., Young, R., Lander, E., and Hacohen, N. (2001) Science 294, 870PubMedCrossRefGoogle Scholar
  6. 6.
    Janeway, C., Jr. (1989) Cold Spring Harb Symp Quant Biol 54, 1PubMedGoogle Scholar
  7. 7.
    Means, T., Golenbock, D., and Fenton, M. (2000) Life Sci 68, 241PubMedCrossRefGoogle Scholar
  8. 8.
    Kaisho, T., and Akira, S. (2002) Biochim Biophy Acta 1589, 1CrossRefGoogle Scholar
  9. 9.
    Takeda, K., and Akira, S. (2003) Cell Microbiol 5, 143PubMedCrossRefGoogle Scholar
  10. 10.
    Aderem, A., and Ulevitch, R. (2000) Nature 406, 782PubMedCrossRefGoogle Scholar
  11. 11.
    Means, T., Golenbock, D., and Fenton, M. (2000) Cytokine Growth Factor Rev 11, 219PubMedCrossRefGoogle Scholar
  12. 12.
    Takeuchi, O., and Akira, S. (2002) Curr Top Microbiol Immunol 270, 155PubMedGoogle Scholar
  13. 13.
    Krieg, A. (2002) Annu Rev Immunol 20, 709PubMedCrossRefGoogle Scholar
  14. 14.
    Gewirtz, A., and Navas, T. (2001) J Immunol 167, 1882PubMedGoogle Scholar
  15. 15.
    Medzhitov, R., Preston-Hurlburt, P., and Janeway, C., Jr. (1997) Nature 388, 394PubMedCrossRefGoogle Scholar
  16. 16.
    Lu, Y., Yeh, W., and Ohashi, P. (2008) Cytokine Growth Factor Rev 42, 145Google Scholar
  17. 17.
    Goto, S., Sakai, S., Kera, J., Suma, Y., Soma, G., and Takeuchi, S. (1996) Cancer Immunol Immunother 42, 255PubMedCrossRefGoogle Scholar
  18. 18.
    Baldridge, J., McGowan, P., Evans, J., Cluff, C., Mossman, S., Johnson, D., and Persing, D. (2004) Expert Opin Biol Ther 4, 1129PubMedCrossRefGoogle Scholar
  19. 19.
    Johnson, D. (2008) Curr Top Med Chem 8, 64PubMedCrossRefGoogle Scholar
  20. 20.
    Lee, C., Wu, C., and Shiau, A. (2008) Clin Cancer Res 14, 1905PubMedCrossRefGoogle Scholar
  21. 21.
    Akazawa, T., Masuda, H., and Saeki, Y. (2004) Cancer Res 64, 757PubMedCrossRefGoogle Scholar
  22. 22.
    Lamm, D., Thor, D., Harris, S., Reyna, J., Stogdill, V., and Radwin, H. (1980) J Urol 124, 38PubMedGoogle Scholar
  23. 23.
    Perabo, F., and Muller, S. (2004) Urology 64, 409PubMedCrossRefGoogle Scholar
  24. 24.
    Witjes, J., and Hendricksen, K. (2008) Eur Urol 53, 45PubMedCrossRefGoogle Scholar
  25. 25.
    Kaasinen, E., Rintala, E., Pere, A., Kallio, J., Puolakka, V., Liukkonen, T., and Tuhkanen, K. (2000) J Urol 164, 47PubMedCrossRefGoogle Scholar
  26. 26.
    Murata, M. (2008) Cancer Sci 99, 1435PubMedCrossRefGoogle Scholar
  27. 27.
    Okamoto, M., Oshikawa, T., and Tano, T. (2003) J Natl Cancer Inst 95, 316PubMedCrossRefGoogle Scholar
  28. 28.
    Oshikawa, T., Okamoto, M., and Tano, T. (2006) J Immunother 29, 143PubMedCrossRefGoogle Scholar
  29. 29.
    Okamoto, M., Furuichi, S., and Nishioka, Y. (2004) Cancer Res 64, 5461PubMedCrossRefGoogle Scholar
  30. 30.
    Tano, T., Okamoto, M., Oshikawa, T., Ahmed, S., Sasai, A., and Sato, M. (2005) Gan To Kagaku Ryoho 32, 1562PubMedGoogle Scholar
  31. 31.
    Apetoh, L., Ghiringhelli, F., and Tesniere, A. (2007) Nat Med 13, 1050PubMedCrossRefGoogle Scholar
  32. 32.
    Apetoh, L., Tesniere, A., Ghiringhelli, F., Kroemer, G., and Zitvogel, L. (2008) Cancer Res 68, 4026PubMedCrossRefGoogle Scholar
  33. 33.
    Shiratsuchi, A., Watanabe, I., Takeuchi, O., Akira, S., and Nakanishi, Y. (2004) J Immunol 172, 2039PubMedGoogle Scholar
  34. 34.
    Chang, C., Tsai, Y., He, L., Wu, T., and Hung, C. (2007) Cancer Res 67, 10047PubMedCrossRefGoogle Scholar
  35. 35.
    Fukata, M., and Abreu, M. (2008) Oncogene 27, 234PubMedCrossRefGoogle Scholar
  36. 36.
    Cochi, K., Ichikura, T., and Kinoshita, M. (2008) Clin Cancer Res 14, 2909CrossRefGoogle Scholar
  37. 37.
    Fukata, M., Chen, A., and Vamadevan, A. (2007) Gastroenterology 133, 1869PubMedCrossRefGoogle Scholar
  38. 38.
    Sun, Q., Liu, Q., Zheng, Y., and Cao, X. (2008) Mol Immunol 45, 2929PubMedCrossRefGoogle Scholar
  39. 39.
    He, W., Liu, Q., Wang, L., Chen, W., Li, N., and Cao, X. (2007) Mol Immunol 44, 2850PubMedCrossRefGoogle Scholar
  40. 40.
    Huang, B., Zhao, J., and Li, H. (2005) Cancer Res 65, 5009PubMedCrossRefGoogle Scholar
  41. 41.
    Kundu, S., Lee, C., and Billips, B. (2008) Prostate 68, 223PubMedCrossRefGoogle Scholar
  42. 42.
    Pei, Z., Lin, D., Song, X., Li, H., and Yao, H. (2008) Cell Immunol 254, 20Google Scholar
  43. 43.
    Kelly, M., Alvero, A., and Chen, R. (2006) Cancer Res 66, 3859PubMedCrossRefGoogle Scholar
  44. 44.
    Hold, G., Rabkin, C., and Chow, W. (2007) Gastroenterology 132, 905PubMedCrossRefGoogle Scholar
  45. 45.
    Achyut, B., Ghoshal, U., Moorchung, N., and Mittal, B. (2007) Hum Immunol 68, 901PubMedCrossRefGoogle Scholar
  46. 46.
    Zheng, S., Augustsson-Balter, K., and Chang, B. (2004) Cancer Res 64, 2918PubMedCrossRefGoogle Scholar
  47. 47.
    El-Omar, E., Ng, M., and Hold, G. (2008) Oncogene 27, 244PubMedCrossRefGoogle Scholar
  48. 48.
    Matsumoto, M., and Seya, T. (2008) Adv Drug Deliv Rev 60, 805PubMedCrossRefGoogle Scholar
  49. 49.
    Kumar, A., Yang, Y., Flati, V., Der, S., Kadereit, S., Deb, A., Haque, J., Reis, L., Weissmann, C., and Williams, B. (1997) EMBO J 16, 406PubMedCrossRefGoogle Scholar
  50. 50.
    Khabar, K., Dhalla, M., Siddiqui, Y., Zhou, A., Al Ahdal, M., Der, S., Silverman, R., and Williams, B. (2000) J Interferon Cytokine Res 20, 653PubMedCrossRefGoogle Scholar
  51. 51.
    Zhou, A., Paranjape, J., Brown, T., Nie, H., Naik, S., Dong, B., Chang, A., Trapp, B., Fairchild, R., Comenares, C., and Silverman, R. (1997) EMBO J 16, 6355PubMedCrossRefGoogle Scholar
  52. 52.
    Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., and Fujita, T. (2004) Nat Immunol 5, 730PubMedCrossRefGoogle Scholar
  53. 53.
    Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy, E., Loo, Y., Gale, M. J., Akira, S., Yonehara, S., Kato, A., and Fujita, T. (2005) J Immunol 175, 2851PubMedGoogle Scholar
  54. 54.
    Alexopoulou, L., Holt, A., Medzhitov, R., and Flavell, R. (2001) Nature 413, 732PubMedCrossRefGoogle Scholar
  55. 55.
    Kabelitz, D. (2007) Curr Opin Immunol 19, 39PubMedCrossRefGoogle Scholar
  56. 56.
    Jiang, Q., Wei, H., and Tian, Z. (2008) J Immunother 31, 555PubMedCrossRefGoogle Scholar
  57. 57.
    Heinz, S., Haehnel, V., Karaghiosoff, M., Schwarzfischer, L., Muller, M., Krause, S., and Rehli, M. (2003) J Biol Chem 278, 21502PubMedCrossRefGoogle Scholar
  58. 58.
    Applequist, S., Wallin, R., and Ljunggren, H. (2002) Int Immunol 14, 1065PubMedCrossRefGoogle Scholar
  59. 59.
    Levy, H., Law, L., and Rabson, A. (1969) Proc Natl Acad Sci USA 62, 357PubMedCrossRefGoogle Scholar
  60. 60.
    Bart, R., Kopf, A., and Silagi, S. (1971) J Invest Dermatol 56, 33PubMedCrossRefGoogle Scholar
  61. 61.
    Turner, W., Chan, S., and Chirigos, M. (1970) Proc Soc Exp Biol Med 133, 334PubMedGoogle Scholar
  62. 62.
    Fisher, J., Cooperband, S., and Mannick, J. (1972) Cancer Res 32, 889PubMedGoogle Scholar
  63. 63.
    Droller, M., and Gomolka, D. (1982) Cancer Res 42, 5038PubMedGoogle Scholar
  64. 64.
    Chapekar, M., and Glazer, R. (1986) Cancer Res 46, 1698PubMedGoogle Scholar
  65. 65.
    Whitmore, M., DeVeer, M., Edling, A., Oates, R., Simons, B., Lindner, D., and Williams, B. (2004) Cancer Res 64, 5850PubMedCrossRefGoogle Scholar
  66. 66.
    Cella, M., Salio, M., Sakakibara, Y., Langen, H., Julkunen, I., and Lanzavecchia, A. (1999) J Exp Med 189, 821PubMedCrossRefGoogle Scholar
  67. 67.
    Le Bon, A., Etchart, N., Rossmann, C., Ashton, M., Hou, S., Gewert, D., Borrow, P., and Tough, D. (2003) Nat Immunol 4, 1009PubMedCrossRefGoogle Scholar
  68. 68.
    Khan, A., Heys, S., and Eremin, O. (1995) Eur J Surg Oncol 21, 224PubMedCrossRefGoogle Scholar
  69. 69.
    Seya, T., Akazawa, T., Uehori, J., Matsumoto, M., Azuma, I., and Toyoshima, K. (2003) Anticancer Res 23, 4369PubMedGoogle Scholar
  70. 70.
    Smits, E., Ponsaerts, P., Van de Velde, A., Van Driessche, A., Cools, N., Lnejou, M., Nijs, G., Van Bockstaele, D., Berneman, Z., and Van Tendeloo, V. (2007) Leukemia 21, 1691PubMedCrossRefGoogle Scholar
  71. 71.
    McBride, S., Hoebe, K., Georgel, P., and Janssen, E. (2006) J Immunol 177, 6122PubMedGoogle Scholar
  72. 72.
    Fujimura, T., Nakagawa, S., Ohtani, T., Ito, Y., and Aiba, S. (2006) Eur J Immunol 36, 3371PubMedCrossRefGoogle Scholar
  73. 73.
    Michiels, A., Breckpot, K., Corthals, J., Tuyaerts, S., Bonehill, A., Heirman, C., Thielmans, K., and Aerts, J. (2006) Gene Ther 13, 1027PubMedCrossRefGoogle Scholar
  74. 74.
    Salem, M., Kadima, A., Cole, D., and Gillanders, W. (2005) J Immunother 28, 220PubMedCrossRefGoogle Scholar
  75. 75.
    Akazawa, T., Ebihara, T., Okuno, M., Okuda, Y., Shingai, M., Tsujimura, K., Takahashi, T., Ikawa, M., Okabe, M., Inoue, N., Okamoto-Tanaka, M., Ishizaki, H., Miyoshi, J., Matsumoto, M., and Seya, T. (2007) Proc Natl Acad Sci USA 104, 252PubMedCrossRefGoogle Scholar
  76. 76.
    Bonmort, M., Ullrich, E., Mignot, G., Jacobs, B., Chaput, N., and Zitvogel, L. (2007) Biochimie 89, 872PubMedCrossRefGoogle Scholar
  77. 77.
    Chan, C., Crafton, E., Fan, H., Flook, J., Yoshimura, K., Sharica, M., Brockstedt, D., Dubensky, T., Stins, M., Lanier, L., Pardoll, D., and Housseau, F. (2006) Nat Med 12, 207PubMedCrossRefGoogle Scholar
  78. 78.
    Taieb, J., Chaput, N., Menard, C., Apetoh, L., Ullrich, E., Bonmort, M., Pequignot, M., Casares, N., Terme, M., Flament, C., Opolon, P., Lecluse, Y., Metivier, D., Tomasello, E., Vivier, E., Ghiringhelli, F., Martin, F., Klatzmann, D., Poynard, T., Tursz, T., Raposo, G., Yagita, H., Ryffel, B., Kroemer, G., and Zitvogel, L. (2006) Nat Med 12, 214PubMedCrossRefGoogle Scholar
  79. 79.
    Vremec, D., O’Keeffe, M., Hochrein, H., Fuchsberger, M., Caminschi, I., Lahoud, M., and Shortman, K. (2007) Blood 109, 1165PubMedCrossRefGoogle Scholar
  80. 80.
    Sivori, S., Falco, M., Della, C., Carlomagno, S., Vitale, M., Moretta, L., and Moretta, A. (2004) Proc Natl Acad Sci USA 101, 10116PubMedCrossRefGoogle Scholar
  81. 81.
    Jiang, Q., Wei, H., and Tian, Z. (2008) BMC Cancer 8, 12PubMedCrossRefGoogle Scholar
  82. 82.
    Salaun, B., Lebecque, S., Matikainen, S., Rimoldi, D., and Romero, P. (2007) Clin Cancer Res 13, 4565PubMedCrossRefGoogle Scholar
  83. 83.
    Salaun, B., Coste, I., Rissoan, M., Lebecque, S., and Renno, T. (2006) J Immunol 176, 4894PubMedGoogle Scholar
  84. 84.
    Huang, B., Zhao, J., Li, H., He, K., Chen, Y., Chen, S., Mayer, L., Unkeless, J., and Xiong, H. (2005) Cancer Res 65, 5009PubMedCrossRefGoogle Scholar
  85. 85.
    Sebastiani, G., Leveque, G., Lariviere, L., Laroche, L., Skamene, E., Gros, P., and Malo, D. (2000) Genomics 64, 230PubMedCrossRefGoogle Scholar
  86. 86.
    Zarember, K., and Godowski, P. (2002) J Immunol 168, 554PubMedGoogle Scholar
  87. 87.
    Eaves-Pyles, T., Wong, H., Odoms, K., and Pyles, R. (2001) J Immunol 167, 7009PubMedGoogle Scholar
  88. 88.
    Dwyer, J., and Mackay, I. (1972) Int Arch Allergy Appl Immunol 43, 434PubMedCrossRefGoogle Scholar
  89. 89.
    Jeon, S., and Arnon, R. (2002) Viral Immunol 15, 165PubMedCrossRefGoogle Scholar
  90. 90.
    Wyant, T., Tanner, M., and Sztein, M. (1999) Infect Immun 67, 1338PubMedGoogle Scholar
  91. 91.
    Cuadros, C., Lopez-Hernandez, F., Dominguez, A., McClelland, M., and Lustgarten, J. (2004) Infect Immun 72, 2810PubMedCrossRefGoogle Scholar
  92. 92.
    Huleatt, J., Jacobs, A., Tang, J., Desai, P., Kopp, E., Huang, Y., Song, L., Nakaar, V., and Powell, T. (2007) Vaccine 25, 763PubMedCrossRefGoogle Scholar
  93. 93.
    Mizel, S., West, A., and Hantgan, R. (2003) J Biol Chem 278, 23624PubMedCrossRefGoogle Scholar
  94. 94.
    Smith, K., Andersen-Nissen, E., Hayashi, F., Strobe, K., Bergman, M., Barrett, S., Cookson, B., and Aderem, A. (2003) Nat Immunol 4, 1247PubMedCrossRefGoogle Scholar
  95. 95.
    Liaudet, L., Szabo, C., Engenov, O., Murthy, K., Pacher, P., Virag, L., Mabley, J., Marton, A., Soriano, F., Kirov, M., Bjertnaes, L., and Salzman, A. (2003) Shock 19, 131PubMedCrossRefGoogle Scholar
  96. 96.
    Gewirtz, A., Navas, T., Lyons, S., Godowski, P., and Madara, J. (2001) J Immunol 167, 1882PubMedGoogle Scholar
  97. 97.
    McDermott, P., Ciacci-Woolwine, F., Snipes, J., and Mizel, S. (2000) Infect Immun 68, 5525PubMedCrossRefGoogle Scholar
  98. 98.
    Means, T., Hayashi, F., Smith, K., Aderem, A., and Luster, A. (2003) J Immunol 170, 5165PubMedGoogle Scholar
  99.  99.
    Agrawal, S., Agrawal, A., Doughty, B., Gerwitz, A., Blenis, J., Van Dyke, T., and Pulendran, B. (2003) J Immunol 171, 4984PubMedGoogle Scholar
  100. 100.
    Applequist, S., Rollman, E., Wareing, M., Liden, M., Rozell, B., Hinkula, J., and Liunggren, H. (2005) J Immunol 175, 3882PubMedGoogle Scholar
  101. 101.
    Sfondrini, L., Rossini, A., Besusso, D., Merlo, A., Taliabue, E., Menard, S., and Balsari, A. (2006) J Immunol 176, 6624PubMedGoogle Scholar
  102. 102.
    Hooper, L., Wong, M., Thelin, A., Hansson, L., Falk, P., and Gordon, J. (2001) Science 291, 881PubMedCrossRefGoogle Scholar
  103. 103.
    Uematsu, S., Jang, M., Chevrier, N., Guo, Z., Kumagai, Y., Yamamoto, M., Kato, H., Sougawa, N., Matsui, H., Kuwata, H., Hemmi, H., Coban, C., Kawai, T., Ishii, K., Takeuchi, O., Miyasaka, M., Takeda, K., and Akira, S. (2006) Nat Immunol 7, 868PubMedCrossRefGoogle Scholar
  104. 104.
    Rakoff-Nahoum, S., and Medzhitov, R. (2007) Science 317, 124PubMedCrossRefGoogle Scholar
  105. 105.
    Rhee, S., Im, E., and Pothoulakis, C. (2008) Gastroenterology 135, 518PubMedCrossRefGoogle Scholar
  106. 106.
    Agrawal, S., and Kandimalla, E. (2007) Biochem Soc Trans 35, 1461PubMedCrossRefGoogle Scholar
  107. 107.
    Akira, S., and Takeda, K. (2004) Nat Rev Immunol 4, 499PubMedCrossRefGoogle Scholar
  108. 108.
    Spaner, D., and Miller, R. (2005) Leuk Lymphoma 46, 935PubMedCrossRefGoogle Scholar
  109. 109.
    Field, A., Tytell, A., Lampson, G., and Hilleman, M. (1967) Proc Natl Acad Sci USA 58, 1004PubMedCrossRefGoogle Scholar
  110. 110.
    Sidky, Y., Borden, E., Weeks, C., Reiter, M., Hatcher, J., and Bryan, G. (1992) Cancer Res 52, 3528PubMedGoogle Scholar
  111. 111.
    Nakaike, S., Yamagishi, T., Samata, K., Nishida, K., Inazuki, K., Ichihara, T., Migita, Y., Otomo, S., Aihara, H., and Tsukagoshi, S. (1989) Cancer Chemother Pharmacol 23, 135PubMedCrossRefGoogle Scholar
  112. 112.
    Slade, H., Owens, M., Tomai, M., and Miller, R. (1998) Expert Opin Investig Drugs 7, 437PubMedCrossRefGoogle Scholar
  113. 113.
    Testerman, T., Gerster, J., Imbertson, L., Reiter, M., Miller, R., Gibson, S., Wagner, T., and Tomai, M. (1995) J Leukoc Biol 58, 365PubMedGoogle Scholar
  114. 114.
    Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., and Akira, S. (2002) Nat Immunol 3, 196PubMedCrossRefGoogle Scholar
  115. 115.
    Suzuki, H., Wang, B., Shivji, G., Toto, P., Amerio, P., Tomai, M., Miller, R., and Sauder, D. (2000) J Invest Dermatol 114, 135PubMedCrossRefGoogle Scholar
  116. 116.
    Ito, T., Amakawa, R., Kaisho, T., Hemmi, H., Tajima, K., Uehira, K., Ozaki, Y., Tomizawa, H., Akira, S., and Fukuhara, S. (2002) J Exp Med 195, 1507PubMedCrossRefGoogle Scholar
  117. 117.
    Gibson, S., Lindh, J., Riter, T., Gleason, R., Rogers, L., Fuller, A., Oesterich, J., Gorden, K., Qiu, X., McKane, S., Noelle, R., Miller, R., Kedl, R., Fitzgerald-Bocarsly, P., Tomai, M., and Vasilakos, J. (2002) Cell Immunol 218, 74PubMedCrossRefGoogle Scholar
  118. 118.
    Rechsteiner, G., and Warger, T. (2005) J Immunol 174, 2476Google Scholar
  119. 119.
    Spaner, D., Shi, Y., White, D., Mena, J., Hammond, C., Tomic, J., He, L., Tomai, M., Miller, R., Booth, J., and Radvanyi, L. (2006) Leukemia 20, 286PubMedCrossRefGoogle Scholar
  120. 120.
    Urosevic, M., Oberholzer, P., Maier, T., Hafner, J., Laine, E., Slade, H., Benninghoff, B., Burg, G., and Dummer, R. (2004) Clin Cancer Res 10, 4959PubMedCrossRefGoogle Scholar
  121. 121.
    Majewski, S., Marczak, M., Mlynarczyk, B., Benninghoff, B., and Jablonska, S. (2005) Int J Dermatol 44, 14PubMedCrossRefGoogle Scholar
  122. 122.
    Stary, G., Bangert, C., Tauber, M., Strohal, R., Kopp, T., and Stingle, G. (2007) J Exp Med 204, 1441PubMedCrossRefGoogle Scholar
  123. 123.
    Dudek, A., Yunis, C., Harrison, L., Kumar, S., Hawkinson, R., Cooley, S., Vasilakos, J., Gorski, K., and Miller, J. (2007) Clin Cancer Res 13, 7119PubMedCrossRefGoogle Scholar
  124. 124.
    Adams, S., O’Neill, D., Nonaka, D., Hardin, E., Chiriboga, L., Siu, K., Cruz, C., Angiulli, A., Angiulli, F., Ritter, E., Holman, R., Shapiro, R., Berman, R., Berner, N., Shao, Y., Manches, O., Pan, L., Venhaus, R., Hoffman, E., Jungbluth, A., Gnjatic, S., Old, L., Pavlick, A., and Bhardwaj, N. (2008) J Immunol 181, 776PubMedGoogle Scholar
  125. 125.
    Shackleton, M., Davis, I., Hopkins, W., Jackson, H., Dimopoulos, N., Tai, T., Chen, Q., Jefford, M., Masterman, K., Caron, D., Chen, W., Maraskovsky, E., and Cebon, J. (2004) Cancer Immun 4, 9PubMedGoogle Scholar
  126. 126.
    Wiemann, B., and Starnes, C. (1994) Pharmacol Ther 64, 529PubMedCrossRefGoogle Scholar
  127. 127.
    Krieg, A. M. (2002) Annu Rev Immunol 20, 709PubMedCrossRefGoogle Scholar
  128. 128.
    Messina, J., Gilkeson, G., and Pisetsky, D. (1991) J Immunol 147, 1759PubMedGoogle Scholar
  129. 129.
    Bauer, S., Pigisch, S., Hangel, D., Kaufmann, A., and Hamm, S. (2008) Immunobiology 213, 315PubMedCrossRefGoogle Scholar
  130. 130.
    Ballas, Z., Rasmussen, W., and Krieg, A. (1996) J Immunol 157, 1840PubMedGoogle Scholar
  131. 131.
    Klinman, D. (2004) Rev Immunol 4, 249Google Scholar
  132. 132.
    Iwasaki, A., and Medzhitov, R. (2004) Nature Immunol 5, 987CrossRefGoogle Scholar
  133. 133.
    Kunikata, N., Sano, K., Honda, M., Ishii, K., Matsunaga, J., Okuyama, R., Takahashi, K., Watanabe, H., Tamura, G., Tagami, H., and Terui, T. (2004) J Invest Dermatol 123, 395PubMedCrossRefGoogle Scholar
  134. 134.
    Wickstrom, E. (1997) Antisense Nucleic Acid Drug Dev 7, 225PubMedGoogle Scholar
  135. 135.
    Smith, J., and Wickstrom, E. (1998) J Natl Cancer Inst 90, 1146PubMedCrossRefGoogle Scholar
  136. 136.
    Ballas, Z., Krieg, A., Warren, T., Rasmussen, W., Davis, H., Waldschmidt, M., and Weiner, G. (2001) J Immunol 167, 4878PubMedGoogle Scholar
  137. 137.
    Carpentier, A., Chen, L., Maltoni, F., and Delattre, J. (1999) Cancer Res 59, 5429PubMedGoogle Scholar
  138. 138.
    Blazar, B., Krieg, A., and Taylor, P. (2001) Blood 98, 1217PubMedCrossRefGoogle Scholar
  139. 139.
    Sharma, S., Dominguez, A., Manrique, S., Cavallo, F., Sakaguchi, S., and Lustgarten, J. (2008) Cancer Res 68, 7530PubMedCrossRefGoogle Scholar
  140. 140.
    Sharma, S., Dominguez, A., Hoelzinger, D., and Lustgarten, J. (2008) Cancer Immunol Immunother 57, 549PubMedCrossRefGoogle Scholar
  141. 141.
    Carpentier, A., Laigle-Donadey, F., Zohar, S., Capelle, L., Behin, A., Tibi, A., Martin-Duverneuil, N., Sanson, M., Lacomblez, L., Tailibert, S., Puybasset, L., Van Effenterre, R., Delattre, J., and Carpentier, A. (2006) Neuro Oncol 8, 60PubMedCrossRefGoogle Scholar
  142. 142.
    Leonard, J., Link, B., Emmanouilides, C., Gregory, S., Weisdorf, D., Audrey, J., Hainsworth, J., Sparano, J., Tsai, D., Horning, S., Krieg, A., and Weiner, G. (2007) Clin Cancer Res 13, 6168PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Joseph Lustgarten
    • 1
  • Dominique Hoelzinger
  • Maria Adelaida Duque
  • Shannon Smith
  • Noweeda Mirza
  1. 1.Cancer Center ScottsdaleMayo Clinic Arizona13400 East Shea Boulevard ScottsdaleUSA

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