Magnetic Resonance Imaging of Pharmacological Systems

  • Hanbing Lu
  • Thomas J. Ross
  • Elliot A. Stein


With the appropriate hardware, pulse sequences and analysis methods, modern MRI research is able to measure numerous neurobiologically relevant parameters including functional activation (fMRI) using blood oxygen level dependent, diffusion tensor imaging – either to measure integrity of white matter or to follow white matter fiber tracts, MR spectroscopy, changes in cerebral blood flow, cerebral blood volume and oxygen metabolism (CMRO2) and of course its more traditional applications to measure, qualitatively and recently quantitatively, brain anatomy. More recently, investigators have added various pharmacological probes to research paradigms to better mechanistically understand both the healthy and diseased brain. This chapter outlines some of the issues related to using pharmacological agents in MRI studies, some of the research question applications, limitations and potential pitfalls.


Cerebral Blood Flow Independent Component Analysis Cerebral Blood Volume Blood Oxygen Level Dependent Independent Component Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.National Institute on Drug Abuse, Intramural Research Program, Neuroimaging Research BranchNational Institutes of HealthBaltimoreUSA

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