Reasons to Believe: The Potential of Imaging in CNS Drug Development
Despite major scientific and technological advances in drug discovery over the past 10–15 years, the success rate of compounds in clinical development has continued to decline. This trend is particularly pronounced for diseases of the central nervous system (CNS). Neuroimaging, while not new to the domain of drug development, has in recent years brought a wealth of new technological advances that may be highly useful in drug development. In the present chapter, we provide an overview of the challenges and opportunities that neuroimaging may provide in transformation and enhancement of CNS drug development from aspects of animal to human translation, CNS target engagement, and the use in defining a phenotype in clinical conditions affecting the CNS.