Cancer Stem Cells: Potential Mediators of Therapeutic Resistance and Novel Targets of Anti-cancer Treatments


Over the last decade, anti-cancer therapies (chemotherapy and radiation, hormonal, neoadjuvant, and combinatorial therapies) have prolonged the lives of cancer patients. However, present cancer therapies fail in a high percentage of cases due to an incomplete elimination of the tumor cells, resulting in relapse and metastasis of the tumor. The vast majority of cancer-related deaths are due to metastatic tumor growth that impairs the function of vital organ(s). Thus, cancer relapse and metastasis are the major challenges in fighting cancer.


Cancer Stem Cell Side Population Mitochondrial Permeability Transition Pore Mitochondrial Permeability Transition Pore Side Population Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank all current and past Tang lab members for their support and helpful discussions. We apologize to those colleagues whose original work could not be cited in this chapter due to space constraint. This work was supported in part by grants from NIH (R01-AG023374, R01-ES015888, and R21-ES015893-01A1), American Cancer Society (RSG MGO-105961), Department of Defense (W81XWH-07-1-0616 & W81XWH-08-1-0472), Prostate Cancer Foundation, and Elsa Pardee Foundation (D.G.T) and by two Center Grants (CCSG-5 P30 CA166672 and ES07784). JQ was supported by a post-doctoral fellowship from DOD and HY was supported by a fellowship grant from the Chinese Ministry of Education.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of CarcinogenesisUniversity of Texas M.D Anderson Cancer Center, Science Park-Research Division, 1808 Park Rd. 1C, Smithville, TX 78957; Program in Molecular Carcinogenesis, Graduate School of Biomedical Sciences (GSBS), The University of Texas Health Science CenterHoustonUSA
  2. 2.Department of EpidemiologyWuhan University School of Public HealthWuhanChina
  3. 3.Program in Molecular Carcinogenesis, Graduate School of Biomedical Sciences (GSBS)The University of Texas Health Science CenterHoustonUSA

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