Adverse Health Effects of Pesticides in Agrarian Populations of Developing Countries

  • Chandrasekharan Nair Kesavachandran
  • Mohammad Fareed
  • Manoj Kumar Pathak
  • Vipin Bihari
  • Neeraj Mathur
  • Anup Kumar Srivastava

In low- and middle-income countries, and across the world, the need to ensure local agricultural production and food security, while simultaneously protecting the population against health affects from pesticide exposure, has emerged as a major public health challenge. As agricultural production in Africa intensifies, and as pesticide use becomes more widespread, an increase of pesticide poisoning cases is to be expected (London et al. 2005). Acute poisoning by agricultural pesticides is currently an important cause of human morbidity and mortality worldwide, with some 25 million farm workers annually exposed to pesticides in developing countries (Jeyaratnam 1990). Developing countries use only 20% of the world’s agrochemicals, yet they suffer 99% of deaths from pesticide poisoning (Jeyaratnam and Chia 1994). The World Health Organization (WHO) estimates that at the global level, 3 million severe pesticide poisoning episodes occur annually, and of these, a minimum of 300,000 people die, with 99% of cases being from low- and middle-income countries (Gunnell and Eddleson 2003). Japanese farmers use an estimated 400,000 t of pesticides per annum, and the number of deaths caused by such pesticide use is about 1,000 persons per annum (in the early 2000s; Nagami et al. 2005). The Poison Information Centre of the National Institute of Occupational Health, in Ahmedabad, reported that organophosphorus (OP) pesticides were responsible for the maximum number of poisonings (73%) among all agricultural chemicals (Dewan and Sayed 1998).

References

  1. Acquavella J, Olsen G, Cole P, Ireland B, Kaneene J, Schuman S, Holden L (1998) Cancer among farmers: a meta-analysis. Ann Epidemiol 8: 64–74.CrossRefGoogle Scholar
  2. Axelson O (1987) Pesticides and cancer risk in agriculture. Med Oncol Tumor Pharmacother 4: 207–217.Google Scholar
  3. Barbosa ER, Leiros D, Costa MD, Bacheschi LA, Scaff M, Leite CC (2001) Parkinsonism after glycine-derivate exposure. Mov Disord 16: 565–568.CrossRefGoogle Scholar
  4. Bhalli JA, Khan QM, Haq MA, Khalid AM, Nasim A (2006) Cytogenetic analysis of Pakistani individuals occupationally exposed to pesticides in a pesticide production industry. Mutagenesis 21(2): 143–148.CrossRefGoogle Scholar
  5. Bhatt MH, Elias MA, Mankodi AK (1999) Acute and reversible parkinsonism due to organophosphate pesticide intoxication: five cases. Neurology 52: 1467–1471.Google Scholar
  6. Blair A, Zahm S (1993) Patterns of pesticide use among farmers: Implications for epidemiologic research. Epidemiol 4: 55–62.CrossRefGoogle Scholar
  7. Blair A, Zahm HS, Pearce N, Heineman EF, Fraumeni JF (1992) Clues to cancer etiology from studies of farmers. Scan J Work Environ Health 18: 209–215.Google Scholar
  8. Brownson R, Reif J, Chang J, Davis J (1990) An analysis of occupational risks for brain cancer. Am J Public Health 80:169–172.CrossRefGoogle Scholar
  9. Chaudhary R, Lall SB, Mishra B, Dhawan B (1998) A food borne outbreak of organophosphate poisoning. Brit Med J 317: 268–269.Google Scholar
  10. Clarke EEK, Levy LS, Spurgeon A, Calvert IA (1997) The problems associated with pesticide use by irrigation workers in Ghana. Occup Med 47(5): 301–308.CrossRefGoogle Scholar
  11. Connell RM, Pacheco F, Wahlberg K, Klein W, Malespin O, Magnotti R, Akerblom M, Murray D (1999) Sub clinical health effects of environmental pesticide contamination in a developing country: cholinesterase depression in children. Environ Res 81: 87–91.CrossRefGoogle Scholar
  12. Crisp TM, Clegg ED, Cooper RL, Anderson DG, Baeteke KP, Hoffmann JL, Morrow MS, Rodier DJ, Schaeffer JE, Touat LW, Zeeman MG, Patel YM (1998) Environmental endocrine disruption: an effects assessment and analysis. Environ Health Perspect 106: 111.CrossRefGoogle Scholar
  13. Dasgupta S, Meisner C, Wheeler D, Xuyen K, Lam NT (2007) Pesticide poisoning of farm workers – implications of blood test results from Vietnam. Int J Hyg Environ Health 210: 121–132.CrossRefGoogle Scholar
  14. Dewan A, Sayed HN (1998) Acute poisonings due to agricultural pesticides reported to the NIOH Poison Information Centre. In: Parikh JR, Gokani VN, Doctor PB, Gandhi DN, Sayed HN (eds). Proceedings of the WHO workshop on occupational health problems in agriculture sector. National Institute of Occupational Health, Ahmedabad, p 131.Google Scholar
  15. Eddleston M (2000) Patterns and problems of deliberate self-poisoning in the developing world. Quart J Med 93: 715–731.Google Scholar
  16. Eddleston M, Phillips MR (2004) Self poisoning with pesticides. Brit Med J 328: 42–44.CrossRefGoogle Scholar
  17. Ejigu D, Mekonnen Y (2005) Pesticide use on agricultural fields and health problems in various activities. E African Med J 82: 427–432.Google Scholar
  18. Ergonen AT, Salacin S, Ozdemir MH (2005) Pesticide use among greenhouse workers in Turkey. J Clin Forensic Med12: 205–208.CrossRefGoogle Scholar
  19. FAO (Food and Agricultural Organization) (2005) Proceedings of Asia regional workshop. Implementation, monitoring and observance: International code of conduct on the distribution and use of pesticides. FAO, Bangkok, Thailand.Google Scholar
  20. Garcia-Perez A, Garcia-Bravo B, Beneit JV (1984) Standard patch tests in agricultural workers. Contact Dermatitis 10: 151–153.CrossRefGoogle Scholar
  21. Government of India (2001) Tenth five-year plan: 2002–2007. Planning Commission of India, New Delhi, pp 513–566. http://planningcommission.nic.in/plans/planrel/fiveyr/welcome.html .
  22. Guo YL, Wang BJ, Lee CC, Wang JD (1996) Prevalence of dermatoses and skin sensitization associated with use of pesticides in fruit farmers of southern Taiwan. Occup Environ Med 53 427–424.CrossRefGoogle Scholar
  23. Gunnell D, Eddleston M (2003) Suicide by intentional ingestion of pesticides: a continuing tragedy in developing countries. Int J Epidemiol 32: 902–909.CrossRefGoogle Scholar
  24. Gupta BN, Mathur N, Rastogi SK, Srivastava AK, Chandra H, Pangtey BS, Mahendra PN, Bharti RS (1995) Socio economic, environmental and health aspects of farm workers engaged in mango plantations. Biomed Environ Sci. 8(4):301–309.Google Scholar
  25. Gupta PK (2004) Pesticide exposure - Indian scene. Toxicol 198: 83–90.CrossRefGoogle Scholar
  26. Hoover R, Blair A (1991) Pesticides and cancer In: Devita V, Hellman S, Rosenberg S (eds) Cancer Prevention. Lippincott, Philadelphia, PA, pp 1–11.Google Scholar
  27. IARC (1987) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans - Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs, Lyon, France, pp 1–42.Google Scholar
  28. IARC Working Group (1991) Occupational exposures in spraying and application of insecticides. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans 53: 45–92.Google Scholar
  29. Indra DP, Bellamy R, Shyamsundar P (2007) Facing hazards at work - agricultural workers and pesticide exposure in Kuttanad, Kerala. South Asian Network for Development and Environmental Economics. 19–07: 1–4.Google Scholar
  30. ITRC (1990) Epidemiological health survey of pesticide sprayers (a report). Industrial Toxicology Research Centre, India.Google Scholar
  31. Jamil K, Das GP, Shaik AP, Dharmi SS, Sudha M (2007) Epidemiological studies of pesticide exposed individuals and their clinical implications. Curr Sci India 92: 340–345.Google Scholar
  32. Jeyaratnam J (1990) Pesticide poisoning: as a major global health problem. World Health Stat Q 43: 139–144.Google Scholar
  33. Jeyaratnam J, Chia KS (1994) Occupational Health in National Development. Singapore: World Scientific.Google Scholar
  34. JPC report (2004) Pesticides and Good Agricultural Practice. Chap. 3. Loksabha secretariat, New Delhi.Google Scholar
  35. Karalliedde L (1999) Organophosphorus poisoning and anaesthesia. Anaesthesia 54: 1073–1088.CrossRefGoogle Scholar
  36. Karunakaran CO (1958) The Kerala food poisoning. J Ind Med Assoc 31: 204–205.Google Scholar
  37. Kesavachandran C, Singh VK, Mathur N, Rastogi1 SK, Siddiqui MKJ, Reddy MMK, Bharti RS, Asif MK (2006a) Possible mechanism of pesticide toxicity related oxidative stress leading to airway narrowing. Redox Rep 11 4: 159–162.CrossRefGoogle Scholar
  38. Kesavachandran C, Rastogi SK, Mathur N (2006b) Health status among pesticide applicators at a mango plantation in India. J Pest Safety Edu 8: 1–9.Google Scholar
  39. Kishi M, Hirschhorn N, Djajadisastra M, Satterlee LN, Strowman S, Dilts R (1995) Relationship of pesticide spraying to signs and symptoms in Indonesian farmers. Scand J Work Environ Health 21: 124–133.Google Scholar
  40. Konstantinova MK, Charlier C, Craen M, Du Caju M, Heinrichs C, Beaufort CD, Plomteux G, Bourguignon JP (2001) Sexual precocity after immigration from developing countries to Belgium: evidence to previous exposure to organochlorine pesticides. Hum Reprod 16 (5):1020–1026.CrossRefGoogle Scholar
  41. Le Couteur DG, McLean AJ, Taylor MC, Woodham BL, Board PG. (1999) Pesticides and Parkinson’s disease. Biomed Pharmacother 53: 122–130.CrossRefGoogle Scholar
  42. Li WM (1986) The role of pesticides in skin disease. Int J Dermatol 25: 295–297.CrossRefGoogle Scholar
  43. Liou HH, Tsai MC, Chen CJ, Jeng JS, Chang YC, Chen SY (1997) Environmental risk factors and Parkinson’s disease: a case-control study in Taiwan. Neurology 48: 1583–1588.Google Scholar
  44. Lisi P, Caraffini S, Assalve D (1987) Irritation and sensitization potential of pesticides. Contact Dermatitis 17: 212–218.CrossRefGoogle Scholar
  45. London L, Flisher AJ, Wesseling C, Mergler D, Kromhout H (2005) Suicide and exposure to organophosphate insecticides: cause or effect? Am J Ind Med 47: 308–321.CrossRefGoogle Scholar
  46. Lydian AM, Berna N, van-Wendel-de-Joode, Peiris-John RJ, van der Hoek W (2003) Neurological symptoms among Sri Lankan farmers occupationally exposed to acetylcholinesterase-inhibiting insecticides. Am J Ind Med 44: 254–264.CrossRefGoogle Scholar
  47. Malik GM, Mubarik M, Romshoo GJ (1998) Organophosphorus poisoning in the Kashmir Valley 1994–97. New Eng J Med 338: 1078.CrossRefGoogle Scholar
  48. Maria CPR, Dario XP, Eloisa DC (2006) Acute poisoning with pesticides in the state of Mato Grosso do Sul, Brazil. Sci Total Environ 357: 88–95.CrossRefGoogle Scholar
  49. Matsushita T, Nomura S, Wakatsuki T (1980) Epidemiology of contact dermatitis from pesticides in Japan. Contact Dermatitis 6: 255–259.CrossRefGoogle Scholar
  50. Meco G, Bonifati V, Vanacore N, Fabrizio E (1994) Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate). Scand J Work Environ Health 20:301–305.Google Scholar
  51. Meyer A, Chrisman J, Moreira JC, Koifman S (2003) Cancer mortality among agricultural workers from serrana region, state of Rio de Janeiro, Brazil. Environ Res 93: 264–271.CrossRefGoogle Scholar
  52. Moses M (1995) Designer poisons: How to protect your health and home from toxic pesticides. Pesticide education centre, San Franscisco, CA.Google Scholar
  53. Musicco M, Filippini G, Bordo E (1982) Gliomas and occupational exposure to carcinogens: case-control study. Am J Epidemiol 116: 782–790.Google Scholar
  54. Nag D, Singh CC, Senon S (1977) Epilepsy endemic due to benzene hexachloride. Trop Geogr Med 29: 229–232.Google Scholar
  55. Nagami H, Nishigaki Y, Matsushima S, Matsushita T, Asanuma S, Yajima N, Usuda M, Hirosawa M (2005) Hospital-based survey of pesticide poisoning in Japan, 1998–2002. Int J Occup Environ Health 11: 180–184.Google Scholar
  56. Nigg HN, Beier RC, Carter O, Chaisson C, Franklin C, Lavy T, Lewis RG, Lombardo P, Mc Carthy IF, Maddy KT, Moses M, Norris D, Peck C, Skinner K, Tardiff RG (1990) The effects of pesticides on human health: exposure to pesticides. In: Advances in Modern Environmental Toxicology. Baker SR, Wilkeson CF (eds), Princeton Science, Princeton, NJ 18:35–130.Google Scholar
  57. Ohayo-Mitoko GJA, Kromhout H, Simwa JM, Boleij JSM, Heederik D (2000) Self reported symptoms and inhibition of acetylcholinesterase activity among Kenyan agricultural workers. Occup Environ Med 57: 195–200.CrossRefGoogle Scholar
  58. O’Malley M (1997) Clinical evaluation of pesticide exposure and poisonings. Lancet 349: 1161–1166.CrossRefGoogle Scholar
  59. PAN UK (2001) The lists of lists. Briefing paper (3). Pesticide Action Network UK. http://www.pan-uk.org/briefing/Listofl.pdf .
  60. Patricia M, Partanen T, Wesseling C, Bravo V, Ruepert C, Burstyn I (2005) Assessment of pesticide exposure in the agricultural population of Costa Rica. Ann Occup Hyg 49(5): 375–384.CrossRefGoogle Scholar
  61. Peiris-John JR, Ruberu KD, Wickremasinghe RA, Lidwien S, van der Hoek W (2002) Effects of occupational exposure to organophosphate pesticides on nerve and neuromuscular function. J Occup Environ Med 44: 352–357.CrossRefGoogle Scholar
  62. Rao SCH, Venkateswarlu V, Surender T, Eddleston M, Buckley NA (2005) Pesticide poisoning in South India: Opportunities for prevention and improved medical management. Trop Med Int Health 10(6): 581–588.CrossRefGoogle Scholar
  63. Rastogi SK, Gupta BN, Husain T, Mathur N, Garg N (1989) Study on respiratory impairment among pesticide sprayers in mango plantations. Am J Ind Med 16: 529–538.Google Scholar
  64. Reif J, Pearce N, Fraser J (1989) Occupational risks for brain cancer: a New Zealand cancer registry-based study. J Occup Med 31: 863–867.CrossRefGoogle Scholar
  65. Rupa DS, Reddy PP, Reddy OS (1991) Reproductive performance in population exposed to pesticides in cotton fields in India. Environ Res 55: 23–126.CrossRefGoogle Scholar
  66. Saiyed HN, Sadhu HG, Bhatnagar VK, Dewan A, Venkaiah K, Kashyap SK (1992) Cardiac toxicity following short term exposure to methomyl in spray-men and rabbits. Human Exp Toxicol 11: 93–95.CrossRefGoogle Scholar
  67. Saiyed HN, Dewan A, Bhatnagar V, Shenoy V, Shenoy R, Rajmohan H, Patel K, Kashyap R, Kulkarni P, Rajan B, Lakkad B (2003) Effect of endosulfan on male reproductive development. Environ Health Persp 111(16): 1958–1962.CrossRefGoogle Scholar
  68. Salameh RP, Baldi I, Brochard P, Saleh BA (2004) Pesticides in Lebanon: a knowledge, attitude and practice study. Environ Res 94: 1–6.CrossRefGoogle Scholar
  69. Sechi G, Agnetti V, Piredda M, Canu M, Deserra F, Omar HA (1992) Acute and persistent parkinsonism after use of diquat. Neurology 42: 261–263.Google Scholar
  70. Senanayake N, Karalliedde L (1986) Acute poisoning in Sri Lanka: an overview. Ceylon Med J 31: 61–71.Google Scholar
  71. Senanayake N (1998) Organophosphorus insecticide poisoning. Ceylon Med J 43: 22–29.Google Scholar
  72. Sethuraman VA (1977) Case of BHC poisoning in a heifer calf. Ind Vet J 54: 486–487.Google Scholar
  73. Singh VK, Jyoti, Reddy MMK, Kesavachandran C, Rastogi SK, Siddiqui MKJ (2007) Biomonitoring of organochlorines, glutathione, lipid peroxidation and cholinesterase activity among pesticide sprayers in mango orchards. Clin Chim Acta 377: 268–272.CrossRefGoogle Scholar
  74. Spiewak R (2001) Pesticides as a cause of occupational skin diseases in farmers. Ann Agric Environ Med 8: 1–5.Google Scholar
  75. Srivastava AK, Gupta BN, Bihari V, Mathur N, Pangtey BS, Bharti RS, Godbole MM (1995) Organochlorine pesticide exposure and thyroid function: a study in human subjects. J Environ Pathol Toxicol Oncol 14(2) 107–110.Google Scholar
  76. Srivastava AK, Gupta BN, Bihari V, Mathur N, Srivastava LP, Pangtey BS, Bharti RS, Kumar P (2000) Clinical, biochemical and neurobehavioral studies of workers engaged in the manufacture of quinalphos. Food Chem Toxicol 38: 65–69.CrossRefGoogle Scholar
  77. Wesseling C, Antich D, Hogstedt C, Rodriguez AC, Ahlbom A (1999) Geographical differences of cancer incidence in Costa Rica in relation to environmental and occupational pesticide exposure. Int J Epidemiol 28: 365–374.CrossRefGoogle Scholar
  78. WHO (2004) The WHO recommended classification of pesticides by hazard and guidelines to classification: WHO. ISBN 92 4 154663 8. <http://www.who.int/ipcs/publications/pesticides_hazard/en/> .
  79. Wingren G, Axelson O (1992) Cluster of brain cancers spuriously suggesting occupational risk among glassworkers. Scand J Work Environ Health 18: 85–89.Google Scholar
  80. Yamashita M, Tanaka J, Ando Y (1997) Human mortality in organophosphate poisonings. Vet Hum Toxicol 39: 84–85.Google Scholar
  81. Yemaneberhan H, Bekele Z, Venn A, Lewis S, Parry E, Britton J (1997) Prevalence of wheeze and asthma and relation to atropy in urban and rural Ethiopia. Lancet 350: 85–90.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Chandrasekharan Nair Kesavachandran
  • Mohammad Fareed
  • Manoj Kumar Pathak
  • Vipin Bihari
  • Neeraj Mathur
  • Anup Kumar Srivastava
    • 1
  1. 1.Epidemiology Section, Indian Institute of Toxicology ResearchCouncil of Scientific & Industrial ResearchLucknowIndia

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