Invasive for sure, the government’s impact on commercialization is enormous. A long alphabet soup of interventions such as OSHA, EPA, FDA, IRS, SEC, PTO, UCC, CE, UL, Sarbanes-Oxley, tariffs, and other applicable laws and regulations affect all technological projects. Issues of control, reporting, and constraints hobble the very best commercial opportunities. Tomes have been written about the massive political and economic shifts taking place at a global level—in material resources, capital, human talent, manufacturing bases, government support, and more. While no one really understands the impact of the shift of manufacturing and services to Asia, for example, it’s clear that there are new metrics for success. This chapter shows how people and companies compete in a world racing into the future.