Advertisement

Effects of Functional Groups, Biosignal Molecules And Nanotopography on Cellular Proliferation

  • H. T. ŞAsmazel
  • S. Manolache
  • M. GÜMÜŞDerelİOĞLu
Conference paper
Part of the NATO Science for Peace and Security Series B: Physics and Biophysics book series (NAPSB)

The aim of this study is the development of novel cell support materials for fibroblast cell cultivation by using low-pressure plasma assisted treatment. Poly(ε-caprolactone) (PCL) membranes were prepared by solvent-casting technique. The plasma assisted treatment was focused on generating a nano-topography and obtaining COOH functionalities on the surface of the membranes. The immobilization of biomolecules onto the PCL membranes was realized after the plasma treatment. The membranes prepared were characterized by various methods before and after the bio-modification. L929 mouse fibroblasts were used for cell culture evaluation. The prominent roles of surface nano-topography and carboxylic groups generated by the plasma in obtaining better cell growth on PCL surfaces are highlighted in this study.

Keywords

poly(ε-caprolactone) low pressure plasma biomolecules immobilization cell proliferation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Y. Ikada, Biomaterials 15, 705 (1994).CrossRefGoogle Scholar
  2. 2.
    M. Gümüşderelioğlu, H. Türkoğlu, Biomaterials 23, 3927 (2002).PubMedCrossRefGoogle Scholar
  3. 3.
    H. Türkoşlu Şaşmazel, S. Manolache, M. Gümüşderelioğlu, J. Biomater. Sci.: Poly. Edition (2009), in press.Google Scholar
  4. 4.
    D. Falconnet, G. Csucs, H.M. Grandin, M. Textor, Biomaterials 27, 3044 (2006).PubMedCrossRefGoogle Scholar
  5. 5.
    Denes, F.S., Manolache, S., Prog. Poly. Sci. 29 (2004).Google Scholar
  6. 6.
    H. Türkoğlu Şaşmazel, M. Gümüşderelioğlu, A. Gürprnar, M.A. Onur, Bio-Med. Mater. Eng. 18, 119 (2008).Google Scholar

Copyright information

© Springer Science + Business Media B.V 2009

Authors and Affiliations

  • H. T. ŞAsmazel
    • 1
  • S. Manolache
    • 1
  • M. GÜMÜŞDerelİOĞLu
    • 1
  1. 1.Department of Materials Engineering, Incek, GölbaşiAtilm UniversityKizilcasar MahallesiTurkey

Personalised recommendations