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Outcome Measures in Bone Metastases Clinical Trials

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Bone Metastases

Part of the book series: Cancer Metastasis – Biology and Treatment ((CMBT,volume 12))

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Abstract

Bone metastases are the most common manifestation of metastatic disease in advanced cancers. Management of bone metastases is increasingly multidisciplinary in nature and as a result, we have witnessed an increased survival of this population. Therefore, there is an increased need to accurately monitor the benefits and side effects of these treatments. This chapter will outline the trials and tribulations that have been encountered leading to the development of standardized outcome assessment tools for use in bone metastases clinical trials. The evaluation of pain response in previous clinical trials and the subsequent establishment of the International Bone Metastases Consensus Working Party endpoints we be explored. This chapter will also discuss various pain assessment tools, when response should be evaluated, and the value of subjective analyses of what constitutes a meaningful pain response for patients. The development of a comprehensive, universal bone metastases-specific quality of life (QOL) questionnaire will be examined, outlining the differences in perspectives of what patients and health care professionals believe to be most relevant issues for patients with bone metastases.

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  1. Department of Radiation Oncology, Odette Cancer Centre, Sunny-brook Health Sciences Centre, University of Toronto, 2075 Bayview Ave, M4N 3M5, Toronto, Ontario, Canada

    Amanda Hird & Edward Chow

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  1. Amanda Hird
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Correspondence to Amanda Hird .

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Editors and Affiliations

  1. Dept. of Radiation Oncology, University of Patras Medical School, 265 04, Patras, Greece

    Dimitrios Kardamakis MD, PhD, DMRT  & Vassilios Vassiliou MD, PhD  & 

  2. Dept. of Radiation Oncology, University of Toronto Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada

    Edward Chow MBBS, PhD, FRCPC

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Hird, A., Chow, E. (2009). Outcome Measures in Bone Metastases Clinical Trials. In: Kardamakis, D., Vassiliou, V., Chow, E. (eds) Bone Metastases. Cancer Metastasis – Biology and Treatment, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9819-2_18

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