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Anti-melanogenic Activity of Ergosterol Peroxide from Ganoderma lucidum on a Mouse Melanoma Cell Line

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Animal Cell Technology: Basic & Applied Aspects

Part of the book series: Animal Cell Technology: Basic & Applied Aspects ((ANICELLTECH,volume 15))

Abstract

MeOH extracts of Ganoderma lucidum showed an inhibitory effect on melanin biosynthesis of a mouse melanoma cell line, B16 10F7. We isolated an active compound from the extract. Physical and chemical data of the active compound were identical to those of ergosterol peroxide. Ergosterol peroxide decreased melanin pigment accumulation over 1 μg/ml by the suppression of melanogenic enzyme in B16 10F7 cells. However, ergosterol, a typical steroid in mushrooms, did not show a marked inhibitory effect on B16 10F7 cell melanogenesis at the same concentrations.

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References

  1. Funasaka, Y., Komoto, M., and Ichihashi, M, 2000, Depigmenting effect of alpha-tocopheryl ferulate on normal human melanocytes, Pigment Cell Res. 13:170–174.

    Article  PubMed  Google Scholar 

  2. Lee, S. H., Choi, S. Y., Kim, H., Hwang, J. S., Lee, B. G., Gao, J. J., and Kim, S. Y., 2002, Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis, Biol. Pharm. Bull. 25:1045–1048.

    Article  CAS  PubMed  Google Scholar 

  3. Miura, N., Hata, K., Tsujimura, N., and Sakamoto, K., 2000, Studies on Ganoderma lucidum-I: The methanol extract from antler-shape fruiting body of Ganoderma lucidum inhibits melanin synthesis in B16 melanoma, Res. Commun. Pharmacol. Toxicol. 5:176–178.

    CAS  Google Scholar 

  4. Hata, K., Iwahori, Y., Hori, K., Okada, Y., and Okuyama Y., 2000, Inhibitory effect of some wild plants in Akita on melanin biosynthesis, Natural Med. 54:144–147.

    Google Scholar 

  5. Hearing, V. J., and Tsukamoto, K., 1991 Enzymatic control of pigmentation in mammals, FASEB J. 5:2902–2909

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Sakamoto Bio Co., Ltd., 25 Kourokuzawa, Yuuwa-Memeki, Akita, 010-1233, Japan

    Toshiyuki Mukaiyama, Noriyuki Tsujimura, Shoko Otaka, Yasuyuki Kosaka & Kenji Sakamoto

  2. Akita Research Institute for Food & Brewing (ARIF), 4-26 Sanuki, Araya-machi, Akita, 010-1623, Japan

    Keishi Hata & Kazuyuki Hori

Authors
  1. Toshiyuki Mukaiyama
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  2. Noriyuki Tsujimura
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  3. Shoko Otaka
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  4. Yasuyuki Kosaka
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  5. Keishi Hata
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  6. Kazuyuki Hori
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  7. Kenji Sakamoto
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Editor information

Editors and Affiliations

  1. Dept. Genetic Resources Technology, Kyushu University, Hakozaki 6-10-1, Fukuoka, 812-8581, Japan

    Sanetaka Shirahata

  2. Dept. Applied Biology, Kyoto Institute of Technology, Matsugasaki, Kyoto, 606-8585, Japan

    Koji Ikura

  3. Graduate School of Biostudies, Kyoto University, Kyoto, 606-8502, Japan

    Masaya Nagao

  4. Dept. Applied Biology, Kyoto Institute of Technology, Matsugasaki, Kyoto, 606-8585, Japan

    Akira Ichikawa

  5. Fac. Agriculture, Kyushu University, Hakozaki, Fukuoka, 812-8581, Japan

    Kiichiro Teruya

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© 2008 Springer Science+Business Media B.V.

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Mukaiyama, T. et al. (2008). Anti-melanogenic Activity of Ergosterol Peroxide from Ganoderma lucidum on a Mouse Melanoma Cell Line. In: Shirahata, S., Ikura, K., Nagao, M., Ichikawa, A., Teruya, K. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 15. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9646-4_42

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