Apoptosis in the Development and Treatment of Laryngeal Cancer: Role of p53, Bcl-2 and Clusterin

  • Maximino Redondo
  • Rafael Fùnez
  • Francisco Esteban

Abstract

In cancer, the balance between proliferation and programmed cell death is disturbed, and defects in apoptotic pathways allow cells with genetic abnormalities to survive. Alterations in apoptotic pathways may result in resistance to drugs and radiation. Such alterations might serve as predictors of chemotherapy- and radiotherapy-sensitivity and, most importantly, as new treatment targets. The proteins p53, bcl-2 and clusterin influence the apoptotic activity of the cells. In this report we describe the distribution and possible functional significance of these proteins in squamous cell carcinoma of the larynx. Their implications in carcinogenesis and progression make these genes worthy of investigation.

Keywords

Laryngeal cancer p53 bcl-2 Clusterin 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Maximino Redondo
    • 1
    • 2
  • Rafael Fùnez
    • 3
    • 2
  • Francisco Esteban
    • 4
    • 5
  1. 1.Department of BiochemistryHospital Costa del Sol
  2. 2.University of MalagaMarbellaSpain
  3. 3.Department of PathologyCIBER Epidemiologia y Salud Publica (CIBERESP), Hospital Costa del SolSpain
  4. 4.Department of OtolaryngologyHospital Virgen del Rocio, Avda.
  5. 5.University of SevillaSevillaSpain

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