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Significance of the Tumour Microenvironment in Radiotherapy

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Cancer Microenvironment and Therapeutic Implications

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Abstract

The growth and development of solid tumours require that they develop a functional vascular supply. But, inadequecies of this primitive and chaotic tumour neo-vasculature result in development of oxygen deprived areas. Hypoxic cells existing in this environment are resistant to radiation therapy. Numerous approaches have been developed to deal with this hypoxia-induced radioresistance. These include increasing oxygen delivery to tumours, chemically radiosensitising hypoxic cells, or killing them with specific cytotoxins. More recent approaches have concentrated on the tumour vascular supply itself. Many of these hypoxia targeted therapies have shown benefit in clinical trials, but while additional testing is ongoing for some of them, newer agents are continually being developed.

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Authors and Affiliations

  1. Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK-8000 Aarhus C, Denmark

    Michael R. Horsman

  2. Department of Radiation Oncology, University of Florida, Shands Cancer Center, Gainesville, Florida, USA

    Dietmar W. Siemann

Authors
  1. Michael R. Horsman
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  2. Dietmar W. Siemann
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Correspondence to Michael R. Horsman .

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Editors and Affiliations

  1. Legnano (Mi) and Radiotherapy / Hyperthermia Department, Policlinico di Monza, Via Amati, 111, 20052 Monza, Italy

    Gianfranco Baronzio

  2. Oncology Department, San Giuseppe Hospital, Via Giovanni Boccaccio, 18, 50053 Empoli, Italy

    Gianfranco Fiorentini

  3. University of Florida, 1600 SW. Archer Road, P.O.Box 100278, Gainesville, FL 32610-0278, USA

    Christopher R. Cogle

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Horsman, M.R., Siemann, D.W. (2009). Significance of the Tumour Microenvironment in Radiotherapy. In: Baronzio, G., Fiorentini, G., Cogle, C.R. (eds) Cancer Microenvironment and Therapeutic Implications. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9576-4_8

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