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Barriers to Drug Delivery in Cancer: Clinical Implications

  • Chapter
Cancer Microenvironment and Therapeutic Implications

Abstract

Abstract

A drug to be effective must satisfy two important requirements. First, it must act on diseased tissue sparing healthy tissue, second it must reach target tissue at adequate concentration to perform its therapeutic effect. As reported by several authors, conventional cancer treatments do not achieve this aim, resulting in suboptimal activity and inability to eradicate tumor tissue. The reasons for this failure are multiple and partially due to the unique physiology of tumor tissue. Tumors develop drug barriers, including high pressure zones and collapsed blood vessels, that make it difficult for blood-borne drugs to reach the tumor’s inner core. In this review, we describe tumor physiology resulting in barriers and forces that govern drug distribution inside tumor regions. Furthermore, we present strategies to overcome these impediments.

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Authors and Affiliations

  1. Consultant Radiohyperthermia Dept, Via Amati 111, Policlinico di Monza, 20052 Monza, Italy

    Gianfranco Baronzio

  2. Department of Animal Biology and IGM-CNR Center for Histochemistry & Cytometry, University of Pavia, Pavia, Italy

    Isabel Freitas

  3. Fellow Department of Pharmacology, University of Novara, 28100 Novara, Italy

    Attilio Baronzio

  4. Chemistry & Biology High School “Istituto Torno”, 20022 Castano P, MI, Italy

    Miriam Baronzio

  5. Fellow Department of Pharmacology, University of Novara, 28100 Novara, Italy

    Elisabetta Crespi

  6. Department of Materials and Production Engineering, University of Naples “Federico II”, Piazzale Tecchio, 80 – 80125 Napoli, Italy

    Paolo Antonio Netti

Authors
  1. Gianfranco Baronzio
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  2. Isabel Freitas
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  3. Attilio Baronzio
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  4. Miriam Baronzio
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  5. Elisabetta Crespi
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  6. Paolo Antonio Netti
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Corresponding author

Correspondence to Gianfranco Baronzio .

Editor information

Editors and Affiliations

  1. Legnano (Mi) and Radiotherapy / Hyperthermia Department, Policlinico di Monza, Via Amati, 111, 20052 Monza, Italy

    Gianfranco Baronzio

  2. Oncology Department, San Giuseppe Hospital, Via Giovanni Boccaccio, 18, 50053 Empoli, Italy

    Gianfranco Fiorentini

  3. University of Florida, 1600 SW. Archer Road, P.O.Box 100278, Gainesville, FL 32610-0278, USA

    Christopher R. Cogle

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© 2009 Springer Science+Business Media B.V.

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Baronzio, G., Freitas, I., Baronzio, A., Baronzio, M., Crespi, E., Netti, P.A. (2009). Barriers to Drug Delivery in Cancer: Clinical Implications. In: Baronzio, G., Fiorentini, G., Cogle, C.R. (eds) Cancer Microenvironment and Therapeutic Implications. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9576-4_5

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