Novel Proteins in α-Synucleinopathies

  • Christine Lund Kragh
  • Poul Henning Jensen
Part of the Focus on Structural Biology book series (FOSB, volume 7)

Abstract

α-Synucleinopathies are a group of neurodegenerative disorders characterized by the presence of intracytoplasmic Lewy bodies in Parkinson’s disease and dementia with Lewy bodies as well as glial cytoplasmic inclusions in multiple system atrophy. The main component of these inclusions is aggregated α-synuclein which supports a strong link between α-synuclein and disease pathogenesis. The mechanisms responsible for α-synuclein aggregation and subsequent degeneration are largely unknown. However, several factors have been shown to accelerate the aggregation of α-synuclein in vitro and suggested to contribute to the pathogenesis of α-synucleinopathies. Several different proteins can stimulate the aggregation process in vitro and have been shown to colocalize with aggregated α-synuclein in pathological brain tissue. We review our current knowledge on proteins with a putative involvement in α-synuclein-dependent degeneration based on aggregatory properties, colocalization with aggregated α-synuclein, or genetic evidence.

Keywords

Dopamine Dementia Oligomer Neurol Parkin 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Christine Lund Kragh
    • 1
  • Poul Henning Jensen
  1. 1.Institute of Medical BiochemistryUniversity of Aarhus Ole Worms Allé 1.170 DK-8000 Aarhus CDenmark

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