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Protein-Based Neuropathology and Molecular Classification of Human Neurodegenerative Diseases

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Book cover Protein Folding and Misfolding: Neurodegenerative Diseases

Part of the book series: Focus on Structural Biology ((FOSB,volume 7))

Abstract

Neurodegenerative diseases are characterized by death and progressive loss of neurons in distinct areas of the central nervous system. Classification is based on clinical presentation, anatomical regions affected, inclusion bearing cell-types and conformationally altered proteins involved in the process. In this chapter, the current molecular pathological classification of neurodegenerative diseases is reviewed by summarizing the proteins relevant for neurodegenerative diseases and their morphological types as extra- and intracellular deposits.

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  1. Institute of Neurology, Medical University of Vienna, POB 48, AKH 4J, A-1097 Wien, Austria

    Gabor G. Kovacs

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  1. Hungarian Academy of Sciences, Biological Research Center Institute of Enzymology, Karolina út 29, 1113, Budapest, Hungary

    Judit Ovádi  & Ferenc Orosz  & 

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Kovacs, G.G., Budka, H. (2009). Protein-Based Neuropathology and Molecular Classification of Human Neurodegenerative Diseases. In: Ovádi, J., Orosz, F. (eds) Protein Folding and Misfolding: Neurodegenerative Diseases. Focus on Structural Biology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9434-7_11

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