Epigenomics pp 321-341 | Cite as

Genome Defense: The Neurospora Paradigm

  • M.R. Rountree
  • E.U. Selker


Eukaryotes deploy an array of defensive mechanisms to limit the destructive effects of “selfish” DNA. These protective mechanisms include both transcriptional gene silencing (TGS) and RNA-based post-transcriptional gene silencing (PTGS) mechanisms. The filamentous fungus Neurospora crassa defends its genome with incredible tenacity utilizing two TGS mechanisms, repeat-induced point mutation (RIP) and DNA methylation and two PTGS mechanisms, quelling and meiotic silencing of unpaired DNA (MSUD).


DNA methylation Genome defense MSUD Quelling RIP 


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© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • M.R. Rountree
  • E.U. Selker
    • 1
  1. 1.Institute of Molecular BiologyUniversity of OregonEugene

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