Programming of Impaired Insulin Secretion Versus Sensitivity: Cause or Effect?
A substantial body of evidence suggests that a poor intrauterine milieu elicited by maternal nutritional disturbance, including maternal diabetes or placental insufficiency, may programme susceptibility in the fetus to later development of glucose intolerance and diabetes. Numerous data in animals have allowed possible mechanisms for programming to be proposed. This review of work in several animal models attempts to identify the cellular and molecular mechanisms at the level of the beta-cell and in the insulin sensitive tissues that are involved in the process of events leading to the pathology later in life.
KeywordsAnimal models beta cell diabetes early programming insulin target tissues
Unable to display preview. Download preview PDF.
- Dabelea D., W.C. Knowler and D.J. Pettitt (2000). “Effect of diabetes in pregnancy on offspring: follow-up research in the Pima Indians” J Mat Fetal Med 9(1): 83–88.Google Scholar
- Ozanne, S.E., M.W. Dorling, C.L. Wang and B.T. Nave (2001). “Impaired PI 3-kinase activation in adipocytes from early growth-restricted male rats”. Am J Physiol 280(3): E534–E539.Google Scholar
- Ozanne, S.E., G.S. Olsen, L.L. Hansen, K.J. Tingey, B.T. Nave, C.L.Wang, K. Hartil, C.J. Petry and L. Mosthaf-Seedorf (2003). “Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscle”. J Endocrinol 177(2): 235–241.PubMedCrossRefGoogle Scholar
- Peterside, I.E., M.A. Selak and R.A. Simmons (2003). “Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats”. Am J Physiol Endocrinol Metab 285(6): 1258–1266.Google Scholar
- Petrik, J., B. Reusens, E. Arany, C. Remacle, C. Coelho, J.J. Hoet and D. Hill (1999). “A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor II”. Endocrinology 140(10): 4861–4873.PubMedCrossRefGoogle Scholar
- Sparre, T., B. Reusens, H. Cherif, M.R. Larsen, P. Roepstorff, S.J. Fey, P. Mose Larsen, C. Remacle and J. Nerup (2003). “Intrauterine programming of fetal islet gene expression in rats — effects of maternal protein restriction during gestation revealed by proteome analysis”. Diabetologia 46(11): 1497–1511.PubMedCrossRefGoogle Scholar
- Taylor, P.D., J. McConnell, I.Y. Khan, K. Holemans, K.M. Lawrence, H. Asare-Anane, S.J. Persaud, P. Jones, L. Petrie, M Hanson and L. Poston (2005). “Impaired glucose homeostasis and mito-chondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy”. Am J Physiol Regul Integr Comp Physiol 288(1): R134–R139.PubMedGoogle Scholar
- Van Assche, F.A., F. De Prins, L. Aerts and M. Verjans (1977). “The endocrine pancreas in small for date infants.” Brit J Obst Gynaec 84(10): 751–753.Google Scholar