Programming of Impaired Insulin Secretion Versus Sensitivity: Cause or Effect?

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 646)

A substantial body of evidence suggests that a poor intrauterine milieu elicited by maternal nutritional disturbance, including maternal diabetes or placental insufficiency, may programme susceptibility in the fetus to later development of glucose intolerance and diabetes. Numerous data in animals have allowed possible mechanisms for programming to be proposed. This review of work in several animal models attempts to identify the cellular and molecular mechanisms at the level of the beta-cell and in the insulin sensitive tissues that are involved in the process of events leading to the pathology later in life.

Keywords

Animal models beta cell diabetes early programming insulin target tissues 

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Copyright information

© Springer Science + Business Media B.V 2009

Authors and Affiliations

  1. 1.Laboratoire de Biologie Cellulaire, Institut des Sciences de la VieUniversité catholique de LouvainBelgique

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