Molecular and Cellular Aspects of Macrophage Aging
Macrophages are key cells in innate and adaptive immune function. These cells are involved in the destruction of bacteria, parasites, viruses and tumor cells and lead to the initiation of the inflammatory process. In addition, macrophages are responsible for processing antigens and presenting digested peptides to T-lymphocytes initiating the adaptive immune response. Finally, macrophages participate in the resolution of the inflammatory process by promoting tissue repair. Macrophage functions are affected by aging, thereby contributing to the immunosenescence of adaptive and innate immunity. Here, we summarize data about the effects of aging on macrophages and we discuss the molecular events that could be involved in this process.
Unable to display preview. Download preview PDF.
- Aloisi F (2005) Cytokine production. In: Kettenmann HRRB (ed) Neuroglia. Oxford University Press, New York, pp 285–301Google Scholar
- Cullell-Young M, Barrachina M, Lopez-Lopez C, Gonalons E, Lloberas J, Soler C, Celada A (2001) From transcription to cell surface expression, the induction of MHC class II I-A alpha by interferon-gamma in macrophages is regulated at different levels. Immunogenetics 53:136–144PubMedCrossRefGoogle Scholar
- de la Fuente M, Hernanz A, Guayerbas N, Alvarez P, Alvarado C (2004) Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence. Cell Mol Biol (Noisy-le-grand) 50 Online Pub:OL683–OL690Google Scholar
- Effros RB (2001) Ageing and the immune system. Novartis Found Symp 235:130–139; discussion 139–145, 146–139Google Scholar
- Fazzalari NL, Kuliwaba JS, Atkins GJ, Forwood MR, Findlay DM (2001) The ratio of messenger RNA levels of receptor activator of nuclear factor kappaB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis. J Bone Miner Res 16:1015–1027PubMedCrossRefGoogle Scholar
- Fietta A, Merlini C, De Bernardi PM, Gandola L, Piccioni PD, Grassi C (1993) Non specific immunity in aged healthy subjects and in patients with chronic bronchitis. Aging (Milano) 5:357–361Google Scholar
- Hirokawa K (1977) The thymus and aging. In: Immunology and aging. In: Makinodan TJJE (ed). Plenum Press, New York, pp 51–76Google Scholar
- Hume DA, Robinson AP, MacPherson GG, Gordon S (1983) The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs. J Exp Med 158:1522–1536PubMedCrossRefGoogle Scholar
- Imai T, Nagira M, Takagi S, Kakizaki M, Nishimura M, Wang J, Gray PW, Matsushima K, Yoshie O (1999) Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol 11:81–88PubMedCrossRefGoogle Scholar
- Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124:315–329PubMedCrossRefGoogle Scholar
- Wang CQ, Udupa KB, Xiao H, Lipschitz DA (1995) Effect of age on marrow macrophage number and function. Aging (Milano) 7:379–384Google Scholar
- Yeramian A, Martin L, Serrat N, Arpa L, Soler C, Bertran J, McLeod C, Palacin M, Modolell M, Lloberas J, Celada A (2006b) Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages. J Immunol 176:5918–5924Google Scholar