Role of Dendritic Cells in Aging

  • Anshu Agrawal
  • Sudhanshu Agrawal
  • Sudhir Gupta


Immunesenescence is characterized by a decline in immune functions which is responsible for majority of morbidity and mortality associated with aging. The possible consequences of this progressive aging of the immune system are an increase in autoimmune phenomena, incidence of malignancies and predisposition to infections. Innate immune system is the primary defense against invading pathogens. Moreover, it also initiates and modulates the functions of adaptive immune system. This review focuses on the age-associated changes in the functions of dendritic cells, the major antigen presenting cells of the innate immune system.


Dendritic Cell Adaptive Immune Response Plasmacytoid Dendritic Cell Secondary Lymphoid Organ Human Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Anshu Agrawal
    • 1
  • Sudhanshu Agrawal
    • 1
  • Sudhir Gupta
    • 1
  1. 1.Medical Sciences I, C-240, Division of Basic and Clinical ImmunologyUniversity of CaliforniaIrvineUSA

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