Transcription Factors in Mature B-Cells During Aging

  • Daniela Frasca
  • Richard L. Riley
  • Bonnie B. Blomberg

Abstract

The purpose of this chapter is to give an overview of the age-related changes in the expression and function of the major transcription factors regulating mature B-cells. We also summarize our recent work and show that the age-related defects in Ig class switch are directly related to the decrease in the transcription factor E47 which controls the expression of AID, needed for CSR. The age-associated effects on the expression and function of the transcription factors NF-κ B and Pax-5 are also described. Blimp-1 seems not to be modified by aging. For other transcription factors relevant for mature B-cell functions, such and IRF4 and Notch2, no effects of aging have been reported so far. The defects presented herein for aged B-cells should allow the discovery of mechanisms to improve humoral immune responses in both humans and mice in the near future.

Keywords

Recombination Germinal Serine Proline Myeloma 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Daniela Frasca
    • 1
    • 2
  • Richard L. Riley
    • 1
  • Bonnie B. Blomberg
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.Graduate School of Cell Biology and DevelopmentUniversity of Rome La SapienzaRomeItaly

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