Abstract
Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Axelsen, J. B. and Sneppen, K. (2004) Quantifying the benefits of translation regulation in the unfolded protein response, Phys. Biol. 1, 1–7.
Cherkasova, V. A. and Hinnebusch, A. G. (2003) Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2, Phys. Biol. 17, 859–872.
Jess H. Leber, Sebastian Bernales, P. W. (2004) IRE1-independent gain control of the unfolded protein response, Plos Biol. 2, 235.
Patil (2004) Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response, Plos Biol. 2, 246.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science + Business Media B.V
About this paper
Cite this paper
Trusina, A., Papa, F., Tang, C. (2008). Translation Attenuation Mechanism in Unfolded Protein Response. In: Skjeltorp, A.T., Belushkin, A.V. (eds) Evolution from Cellular to Social Scales. NATO Science for Peace and Security Series B: Physics and Biophysics. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8761-5_6
Download citation
DOI: https://doi.org/10.1007/978-1-4020-8761-5_6
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-8760-8
Online ISBN: 978-1-4020-8761-5
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)