In 1986 Ito and coworkers reported enantioselective aldol additions of methyl isocyanoacetate to aldehydes mediated by chiral ferrocenyl—gold complexes.1,2,3 The corresponding trans-configured oxazolines were obtained with an excellent degree of enantioselectivity (Scheme 3.4.1). By hydrolysis the corresponding β-hydroxy-α-amino acids were obtained. This reaction has been extensively studied by Ito4,5 as well as Togni and coworkers.6,7,8,9,10,11,12
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(2009). Gold- and Rhodium-Catalysed Aldol Additions. In: Mahrwald, R. (eds) Aldol Reactions. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8701-1_17
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