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Antibody Fragments Produced by Recombinant and Proteolytic Methods

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Targeted Radionuclide Tumor Therapy

Summary

While monoclonal antibodies provide the means to specifically target radioisotopes to tumors, the initial clinical radioimmunotherapy trials were largely unsuccessful. In the past decade, the field of molecular biology has matured to the point where we can re-engineer antibodies to overcome the limitations that were likely responsible for the early failures of radioimmunotherapy. In this chapter the wide variety of engineered and proteolytically produced antibody fragments are described along with their potential benefits for radioimmunotherapy.

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Authors and Affiliations

  1. Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA, 19111, USA

    Gregory P. Adams

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  1. Gregory P. Adams
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Editors and Affiliations

  1. Department of Immunology, University of Umea, Umea, Sweden

    Torgny Stigbrand

  2. Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    Jörgen Carlsson

  3. Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, USA

    Gregory P. Adams

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Adams, G.P. (2008). Antibody Fragments Produced by Recombinant and Proteolytic Methods. In: Stigbrand, T., Carlsson, J., Adams, G.P. (eds) Targeted Radionuclide Tumor Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8696-0_5

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