Abstract
This paper examines timescales associated with mechanotransduction and biochemotransduction processes in mammalian adherent cells. The deformation timescales of the cytoskeleton dominate, in certain cases, during mechanotransduction. Viscous damping effects limit the possibility of vibrational instabilities. We conclude that extreme oscillations may lead to cell detachment, while damped oscillations provide favorable environment for the cell growth. Conversely, times associated with diffusion in the cytoplasm limit biochemotransduction. Reaction timescales which do not involve enzymes are larger than the values of all other timescales suggesting that in specific cases, these reactions might be the limiting step. Also, we derive non-dimensional parameters to predict conditions in which gravity has a significant role in mechanotransduction and biochemotransduction.
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© 2008 Springer Science+Business Media B.V.
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Kizito, J., Barlow, K., Ostrach, S. (2008). Characteristic Timescales for Adherent Mammalian Cells. In: Saito, K. (eds) Progress in Scale Modeling. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8682-3_34
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DOI: https://doi.org/10.1007/978-1-4020-8682-3_34
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-8681-6
Online ISBN: 978-1-4020-8682-3
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