Arnica montana and behavior of Connective Tissue

  • Leoni Villano Bonamin

The effects of Arnica montana extracts are known since the middle age (Carvalho, 2000). Due to the wide variety of active principles, vesicular inflammatory cutaneous reaction and analgesic, anti-ulcerative, anti-hypertensive, anti-genotoxic and anti-hemorrhagic effects have been classically described (Genet, 1980; Demarque, 1985; Cerqueira et al., 1987; Chakrabarti, 1991; Robles et al., 1995; Rigamonti, 1995; Chakrabarti et al., 2001; Jeffrey and Belcher, 2002; Macedo et al., 2004). Moreover, its most studied active principle, Helenalin, is the main principle involved in the anti-inflammatory effects (Hall et al., 1980; Schimidt et al., 1993; Bucay, 1995; Lyss et al., 1997; Klass et al., 2002; Macedo et al., 2004). The inflammatory process involves a series of tissue and plasma events, in which several kinds of cells and chemical mediators communicate one to another in a web structured organization. This allows reaching an optimal tissue response to an aggressive stimulus (Cotran et al., 2004). Although the use of Arnica montana in homeopathic preparations in the treatment of acute inflammation is quite traditional, and is even recommended as an emergency treatment of polytraumatic injuries (Oberbaum et al., 2003), there are some controversies in the literature about it (Ernst and Pittler, 1998; Ramelet et al., 2000; Wolf et al., 2003; Stevinson et al., 2003; Macedo et al., 2004; Conforti et al., 2007), thus, more specific studies about physiopathological changes after Arnica treatments are needed.


Mast Cell Acute Inflammation Evans Blue Sesquiterpene Lactone Chemical Mediator 
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© Springer Science+Business Media B.V 2008

Authors and Affiliations

  • Leoni Villano Bonamin
    • 1
    • 2
  1. 1.Universidade PaulistaSão PauloBrazil
  2. 2.Universidade de Santo AmaroSão PauloBrazil

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