Hepatic Cell Growth Models for the Study of Ultra High Dilutions
The regenerative hepatic process has been of interest since Ancient Greek time, according to the Prometheus myth. Nowadays, hepatic regeneration study is incontestable due to its clinical importance. For all the characteristics mentioned below, studies involving hepatic regeneration and hepatic carcinogenesis are a good basic research model to study biological effects of ultra high dilutions in living organisms.
It is well known the majority of the liver is made from hepatocytes, classified as “stable cells”, which means that under normal conditions, they have low “turn over” or low renew rate, with mitotic activity up to 1% (Cotran et al., 2004). However, when a reduction of functional liver parenchyma occurs, due to a lesion or partial ablation of this organ, the proliferation activity increases until 100% of its parenchyma is regenerated. Many serious hepatic diseases such as cirrhosis and hepatocellular carcinoma are a disturbance result of the regenerative process. In the last years, much effort has been dedicated to understand the molecular mechanisms coordinating these processes.
KeywordsLiver Regeneration Partial Hepatectomy Prussian Blue Hepatic Glycogen Hepatic Regeneration
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