New Insight into Mechanisms of Sol-Gel Process and New Materials and Opportunities for Bioencapsula-tion and Biodelivery

Part of the NATO Science for Peace and Security Series C: Environmental Security book series (NAPSC)


The review considers principal mechanisms in solution transformations, hydrolysis and condensation of alkoxysilanes and metal alkoxide complexes and the pathways of further transformations of the thus formed colloid systems. The versatility of silica sol-gel is provided by the possibility to direct the kinetically controlled process towards either polymeric or micellar colloids. The hydrolysis of metal alkoxides is kinetically unhindered and results in formation of Micelles Templated by Self-Assembly of Ligands (MTSALs) under the local equilibrium conditions. The morphology, reactivity, long term stability and biocompatibility of MTSALs can be efficiently controlled by the choice of metal cations, ligands and the conditions of hydrolysis. Application of the MTSAL concept for the synthesis of hierarchically porous materials and the prospects of their use in bioencapsulation and biodelivery for water and soil remediation processes are discussed.


Chemical modification functional ligands micelles templated by self-assembly of ligands (MTSAL) mechanism drug delivery controlled release biocontrol applications soil and water remediation 


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  1. 1.
    J.K. Kim, G.P. Kraemer, C.D. Neefus, I.K. Chung, C. Yarish, J. Appl. Phycol. 19, 431 (2007).CrossRefGoogle Scholar
  2. 2.
    S.B. Yabusaki, Y. Fang, P.E. Long, C.T. Resch, A.D. Peacock, J. Komlos, P.R. Jaffe, S.J. Morrison, R.D. Dayvault, D.C. White, R.T. Anderson, J. Contaminant Hydrol. 93, 216 (2007).CrossRefGoogle Scholar
  3. 3.
    J.D. Kim, C.G. Lee, Biotechnol. Bioproc. Eng. 12, 410 (2007).CrossRefGoogle Scholar
  4. 4.
    M.H. Saier, Water Air Soil Pollut. 184, 1 (2007).CrossRefGoogle Scholar
  5. 5.
    T. Jankowski, M. Zielinska, A. Wysakowska, Biotechnol. Tech. 11, 31 (1997).CrossRefGoogle Scholar
  6. 6.
    T.B. Hammill, R.L. Crawford, Canadian J. Microbiol. 43, 1091 (1997).Google Scholar
  7. 7.
    K.E. Stormo, R.L. Crawford, Appl. Environ. Microb. 58, 727 (1992).Google Scholar
  8. 8.
    C. Bienaime, J.N. Barbotin, J.E. Nava-Saucedo, J. Biomed. Mater. Res. 67A, 376 (2003).Google Scholar
  9. 9.
    J.R. Premkumar, R. Rosen, S. Belkin, O. Lev, Anal. Chim. Acta 462, 11 (2002).CrossRefGoogle Scholar
  10. 10.
    N. Nassif, O. Bouvet, M.N. Rager, C. Roux, T. Coradin, J. Livage, Nat. Mater. 1, 42 (2002).CrossRefGoogle Scholar
  11. 11.
    I.A. Brytov, Y.N. Romashenko, B.F. Shchegolev, J. Struct. Chem. 20, 190 (1979).CrossRefGoogle Scholar
  12. 12.
    L.N. Pankratova, V.V. Zhakhovskii, G.S. Kharitonova, A.Y. Rabkina, B.G. Zavin, Russ. Chem. Bull. 37, 1573 (1988).CrossRefGoogle Scholar
  13. 13.
    A.N. Egorochkin, Russ. Chem. Rev. 54, 786 (1985).CrossRefGoogle Scholar
  14. 14.
    J. Livage, C. Sanchez, J. Non-Cryst. Solids 145, 11 (1992).CrossRefGoogle Scholar
  15. 15.
    D.C. Bradley, R.C. Mehrotra, D. Gaur, Metal Alkoxides (Academic, London) (1978).Google Scholar
  16. 16.
    C.J. Brinker, G.W. Sherer, J. Non-Cryst. Solids 70, 301 (1985).CrossRefGoogle Scholar
  17. 17.
    C.J. Brinker, J. Non-Cryst. Solids 100, 31 (1991).CrossRefGoogle Scholar
  18. 18.
    C.J. Brinker, K.D. Keefer, D.W. Chaefer, R.A. Assink, B.D. Kay, C.S. Ashley, J. Non-Cryst. Solids 63, 45 (1984).CrossRefGoogle Scholar
  19. 19.
    N.W. Mitzel, A.J. Blake, D.W.H. Rankin, J. Am. Chem. Soc. 119, 4143 (1997).CrossRefGoogle Scholar
  20. 20.
    V.W. Day, W.G. Klemperer, V.V. Mainz, D.M. Millar, J. Am. Chem. Soc. 107, 8282 (1985).Google Scholar
  21. 21.
    A.A. Kemme, Y.Y. Bleidelis, I.P. Urtane, G.I. Zelchan, E. Dukevits, J. Struct. Chem. 25, 165 (1984).Google Scholar
  22. 22.
    K.C.K. Swamy, V. Chandrasekhar, J.J. Harland, J.M. Holmes, R.O. Day, R.R. Holmes, J. Am. Chem. Soc. 112, 2341 (1990).CrossRefGoogle Scholar
  23. 23.
    K.Y. Blohowiak, D.R. Treadwell, B.L. Mueller, M.L. Hoppe, S. Jouppi, P. Karsal, K.W. Chew, C.L.S. Scotto, F. Babonneau, J. Kampf, R.M. Laine, Chem. Mater. 6, 2177 (1994).CrossRefGoogle Scholar
  24. 24.
    W. Donharl, I. Elhofer, P. Wiede, U. Schubert, J. Chem. Soc., Dalton Trans. 15, 2445 (1998).CrossRefGoogle Scholar
  25. 25.
    C. Xu, T.H. Baum, A.L. Rheingold, Inorg. Chem. 43, 1568 (2004).CrossRefGoogle Scholar
  26. 26.
    D. Avnir, Acc. Chem. Res. 28, 328 (1995).CrossRefGoogle Scholar
  27. 27.
    D. Avnir, S. Braun, Biochemical Aspects of Sol-Gel Science and Technology (Kluwer, Hingham, MA) (1996).Google Scholar
  28. 28.
    L.M. Ellerby, C.R. Nishida, F. Nishida, F.A. Yamanaka, B. Dunn, J.B. Valentine, J.I. Zink, Science 255, 1113 (1992).CrossRefGoogle Scholar
  29. 29.
    I. Gill, A. Ballesteros, J. Am. Chem. Soc. 120, 8587 (1998).CrossRefGoogle Scholar
  30. 30.
    D. Avnir, S. Braun, O. Lev, M. Ottolenghi, Sol-Gel Optics (Klein L., Ed., Kluwer, Berlin) (1994).Google Scholar
  31. 31.
    D. Avnir, S. Braun, O. Lev, M. Ottolenghi, Chem. Mater. 6, 1605 (1994).CrossRefGoogle Scholar
  32. 32.
    R. Armon, C. Dosoretz, J. Starosvetsky, F. Orshansky, I. Saadi, J. Biotechnol. 51, 279 (1996).CrossRefGoogle Scholar
  33. 33.
    S. Shtelzer, S. Rappoport, D. Avnir, M. Ottolenghi, S. Braun, Biotechnol. Appl. Biochem. 15, 227 (1992).Google Scholar
  34. 34.
    M.T. Reetz, A. Zonta, J. Simplekamp, Angew. Chem., Int. Ed. 34, 301 (1995).CrossRefGoogle Scholar
  35. 35.
    O. Heichal-Segal, S. Rappoport, S. Braun, Biotechnology 13, 798 (1995).CrossRefGoogle Scholar
  36. 36.
    M.T. Reetz, A. Zonta, J. Simplekamp, W. Koenen, Chem. Commun. 1397 (1996).Google Scholar
  37. 37.
    B.C. Dave, B. Dunn, J.S. Valentine, J.I. Zink, Anal. Chem. 66, 1120A (1994).CrossRefGoogle Scholar
  38. 38.
    J. Lin, C.W. Brown, Trends Anal. Chem. 16, 200 (1997).CrossRefGoogle Scholar
  39. 39.
    S. Barreau, J.N. Miller, Anal. Commun. 33, 5H (1996).CrossRefGoogle Scholar
  40. 40.
    B.D. MacCraith, C.M. McDonagh, G. O’Keefe, A.K. McEnvoy, T. Butler, F.R. Sheridan, Sens. Actuators B29, 51 (1995).Google Scholar
  41. 41.
    I. Pankratov, O. Lev, J. Electroanal. Chem. 393, 35 (1995).CrossRefGoogle Scholar
  42. 42.
    J.Y. Barreau, J.M. Da Costa, I. Desportes, J. Livage, M. Monjour, M. Gentilini, Compt. Rend. Acad. Sci., Ser. III 317, 653 (1994).Google Scholar
  43. 43.
    J. Livage, J.Y. Barreau, J.M. Da Costa, I. Desportes, SPIE Proc. 2228, 493 (1994).CrossRefGoogle Scholar
  44. 44.
    J. Livage, C. Roux, J.M. Da Costa, I. Desportes, J.F. Quinson, J. Sol-Gel Sci. Tech. 7, 45 (1996).CrossRefGoogle Scholar
  45. 45.
    R. Wang, U. Narang, P.N. Prasad, F.V. Bright, Anal. Chem. 65, 2671 (1993).CrossRefGoogle Scholar
  46. 46.
    H.H. Weetall, Biosens. Bioelectr. 11, 327 (1996).CrossRefGoogle Scholar
  47. 47.
    S. Wu, L.M. Ellerby, J.S. Cohan, B. Dunn, M.A. El-Sayed, J.S. Valentine, J.I. Zink, Chem. Mater. 5, 115 (1993).CrossRefGoogle Scholar
  48. 48.
    Z. Chen, L.A. Samuelson, J. Akkara, D.L. Kaplan, H. Gao, J. Kumar, K.A. Marx, S.K. Tripathy, Chem. Mater. 7, 1779 (1995).CrossRefGoogle Scholar
  49. 49.
    Z. Chen, D.L. Kaplan, K. Yang, J. Kumar, K.A. Marx, S.K. Tripathy, J. Sol-Gel Sci. Tech. 7, 99 (1996).CrossRefGoogle Scholar
  50. 50.
    E.J.A. Pope, K. Braun, C.M. Peterson, J. Sol-Gel Sci. Tech. 8, 635 (1997).Google Scholar
  51. 51.
    E.J.A. Pope, Ceram. Trans. 63, 17 (1996).Google Scholar
  52. 52.
    U. Narang, M.H. Rahman, J.H. Wang, P.N. Prasad, F.V. Bright, Anal. Chem. 67, 1935 (1995).CrossRefGoogle Scholar
  53. 53.
    I. Gill, Chem. Mater. 13, 3404 (2001).CrossRefGoogle Scholar
  54. 54.
    I. Gill, A. Ballesteros, Angew. Chem., Int. Ed. 42, 3264 (2003).CrossRefGoogle Scholar
  55. 55.
    T. Coradin, E. Marcey, L. Lisnard, J. Livage, Chem. Commun. 2496 (2001).Google Scholar
  56. 56.
    T. Coradin, J. Livage, Compt. Rend. Chim. 6, 147 (2003).CrossRefGoogle Scholar
  57. 57.
    H.R. Luckarift, J.C. Spain, R.R. Naik, M.O. Stone, Nature Biotechnol. 22, 211 (2004).CrossRefGoogle Scholar
  58. 58.
    R. Pedrazzani, G. Bertanza, C. Maffezzoni, M. Gelmi, N. Manca, L.E. Depero, Water Res. 39, 2056 (2005).CrossRefGoogle Scholar
  59. 59.
    D. Avnir, T. Coradin, O. Lev, J. Livage, J. Mater. Chem. 16, 1013 (2006).CrossRefGoogle Scholar
  60. 60.
    G.A. Seisenbaeva, P. Werndrup, L. Kloo, V.G. Kessler, Inorg. Chem. 40, 3815 (2001).CrossRefGoogle Scholar
  61. 61.
    G.A. Seisenbaeva, A.I. Baranov, P.A. Shcheglov, V.G. Kessler, Inorg. Chim. Acta 357, 468 (2004).CrossRefGoogle Scholar
  62. 62.
    K. Gigant, A. Rommel, M. Henry, J. Am. Chem. Soc. 123, 11632 (2001).CrossRefGoogle Scholar
  63. 63.
    J.H. Wengrovius, M.F. Garbauskas, E.A. Williams, R.C. Going, P.E. Donahue, J.F. Smith, J. Am. Chem. Soc. 982, 108 (1986).Google Scholar
  64. 64.
    M.S. Bains, D.C. Bradley, Can. J. Chem. 40, 2218 (1962).CrossRefGoogle Scholar
  65. 65.
    M.S. Bains, D.C. Bradley, Can. J. Chem. 44, 534 (1966).CrossRefGoogle Scholar
  66. 66.
    H. Fric, M. Puchberger, U. Schubert, J. Sol-Gel Sci. Tech. 40, 155 (2006).CrossRefGoogle Scholar
  67. 67.
    K.C. Fortner, J.P. Bigi, S.N. Brown, Inorg. Chem. 44, 2803 (2005).CrossRefGoogle Scholar
  68. 68.
    A. Senouci, M. Yaakoub, C. Huguenard, M. Henry, J. Mater. Chem. 14, 3215 (2004).CrossRefGoogle Scholar
  69. 69.
    G. Westin, U. Bemm, R. Norrestam, M. Nygren, J. Sol-Gel Sci. Tech. 8, 23 (1997).Google Scholar
  70. 70.
    G.A. Seisenbaeva, S. Gohil, V.G. Kessler, J. Mater. Chem. 14, 3177 (2004).CrossRefGoogle Scholar
  71. 71.
    V.G. Kessler, G.I. Spijksma, G.A. Seisenbaeva, S. Håkansson, D.H.A. Blank, H.J.M. Bouwmeester, J. Sol-Gel Sci. Tech. 40, 163 (2006).CrossRefGoogle Scholar
  72. 72.
    G.I. Spijksma, H.J.M. Bouwmeester, D.H.A. Blank, A. Fischer, M. Henry, V.G. Kessler, Inorg. Chem. 44, 9938 (2006).Google Scholar
  73. 73.
    V.G. Kessler, G.A. Seisenbaeva, S. Håkansson, M. Unell, Patent WO 07145573 A1, priority date June 12, 2006.Google Scholar

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© Springer Science + Business Media B.V 2008

Authors and Affiliations

  1. 1.Department of ChemistrySLUUppsalaSweden

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