Recruitment and Retention

  • Stephen P. Glasser


Nothing is more important to a clinical research study than recruiting and then retaining subjects in a study. In addition, losses to follow-up and destroy a study. This chapter will address such issues as to why people participate in clinical research, what strategies can be employed to recruit and then retain subjects in a study, issues involved with minority recruitment, and HIPAA; and, will include some real examples chosen to highlight the retention of potential drop-outs.


Protect Health Information Clinical Research Study Covered Entity Tuskegee Syphilis Study Minority Recruitment 
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  1. 1.
    Charlson ME, Horwitz RI. Applying results of randomised trials to clinical practice: impact of losses before randomisation. Br Med J (Clin Res Ed). Nov 10, 1984; 289(6454):1281–1284.CrossRefGoogle Scholar
  2. 2.
    Easterbrook PJ, Matthews DR. Fate of research studies. J R Soc Med. Feb 1992; 85(2):71–76.PubMedGoogle Scholar
  3. 3.
    A case study in how not to conduct a clinical trial. USA Today, 2000.Google Scholar
  4. 4.
    Wright JR, Bouma S, Dayes I, et al. The importance of reporting patient recruitment details in phase III trials. J Clin Oncol. Feb 20, 2006; 24(6):843–845.PubMedCrossRefGoogle Scholar
  5. 5.
    Gross CP, Mallory R, Heiat A, Krumholz HM. Reporting the recruitment process in clinical trials: who are these patients and how did they get there? Ann Intern Med. July 2, 2002; 137(1):10–16.PubMedGoogle Scholar
  6. 6.
    Morton LM, Cahill J, Hartge P. Reporting participation in epidemiologic studies: a survey of practice. Am J Epidemiol. Feb 1, 2006; 163(3):197–203.PubMedCrossRefGoogle Scholar
  7. 7.
    Halpern SD. Reporting enrollment in clinical trials. Ann Intern Med. Dec 17, 2002; 137(12):1007–1008; author reply 1007–1008.PubMedGoogle Scholar
  8. 8.
    Hewison J, Haines A. Overcoming barriers to recruitment in health research. BMJ. Aug 5, 2006; 333(7562):300–302.CrossRefGoogle Scholar
  9. 9.
    Getz K. Industry trials poised to win back academia after parting ways in the late 90s. Appl Clin Trials. Apr 1, 2007; 2007.Google Scholar
  10. 10.
    Giuffrida A, Torgerson DJ. Should we pay the patient? Review of financial incentives to enhance patient compliance. BMJ. Sept 20, 1997; 315(7110):703–707.PubMedGoogle Scholar
  11. 11.
    Dunn LB, Gordon NE. Improving informed consent and enhancing recruitment for research by understanding economic behavior. JAMA. Feb 2, 2005; 293(5):609–612.PubMedCrossRefGoogle Scholar
  12. 12.
    Jenkins V, Fallowfield L. Reasons for accepting or declining to participate in randomized clinical trials for cancer therapy. Br J Cancer. June 2000; 82(11):1783–1788.PubMedCrossRefGoogle Scholar
  13. 13.
    Hawkins C, West T, Ferzola N, Preismeyer C, Arnett D, Glasser S. Why do patients participate in clinical research? Associates of Clinical Pharmacology 1993 Annual Meeting; 1993.Google Scholar
  14. 14.
    Mapstone J, Elbourne DR, Roberts I. Strategies to improve recruitment in research studies; 2002.Google Scholar
  15. 15.
    Gilliss C, Lee K, Gutierrez Y, et al. Recruitment and Retention of Healthy Minority Women into Community-Based Longitudinal Research. J Womens Health Gender-Based Med. 2001; 10:77–85.CrossRefGoogle Scholar
  16. 16.
    Yancy AK, Ortega AN, Kumanyika SK. Effective recruitment and retention of minority research participants. Annu Rev Public Health. 2006; 27:1–28.CrossRefGoogle Scholar
  17. 17.

Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Stephen P. Glasser
    • 1
  1. 1.Univesity of Alabama at Birmingham, Birmingham, AlabamaBirmingham

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