The Placebo and Nocebo Effect

  • Stephen P. Glasser
  • William Frishman


There are four general reasons for clinical improvement in a patient’s condition: (1) natural history of the disease; (2) specific effects of the treatment; (3) regression to the mean; and (4) nonspecific effects of the treatment that are attributable to factors other than the specific active components. The latter effect is included under the heading ‘placebo effect’. In this chapter the placebo effect will be discussed, with some emphasis on regression to the mean. Placebos (‘I will please’) and their lesser known counterpart’s nocebo’s (I will harm’) are sham treatments. The difference is in the response to the inert therapy. A beneficial response to an inert substance is a placebo response; a side effect to an inert substance is a nocebo response.


Placebo Effect Placebo Control Placebo Response Excellent Adherence Aspirin Group 
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Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Stephen P. Glasser
    • 1
  • William Frishman
    • 2
  1. 1.Univesity of Alabama at Birmingham, Birmingham, AlabamaBirmingham
  2. 2.The Department of MedicineNew York Medical CollegeNew York City

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