Abstract
There are many variations to the classical randomized controlled trial. These variations are utilized when, for a variety of reasons, the classical randomized controlled trial would be impossible, inappropriate, or impractical. Some of the variations are described in this chapter and include: equivalence and noninferiority trials; crossover trials; N of 1 trials, case-crossover trials, and externally controlled trials. Large simple trials, and prospective randomized, open-label, blinded endpoint trials are discussed in another chapter.
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© 2008 Springer Science + Business Media B.V
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Glasser, S.P. (2008). Alternative Interventional Study Designs. In: Glasser, S.P. (eds) Essentials of Clinical Research. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8486-7_4
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DOI: https://doi.org/10.1007/978-1-4020-8486-7_4
Publisher Name: Springer, Dordrecht
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