Alternative Interventional Study Designs
There are many variations to the classical randomized controlled trial. These variations are utilized when, for a variety of reasons, the classical randomized controlled trial would be impossible, inappropriate, or impractical. Some of the variations are described in this chapter and include: equivalence and noninferiority trials; crossover trials; N of 1 trials, case-crossover trials, and externally controlled trials. Large simple trials, and prospective randomized, open-label, blinded endpoint trials are discussed in another chapter.
KeywordsBeta Carotene Assay Sensitivity Crossover Design Investigational Drug Noninferiority Trial
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