Introduction to Clinical Research and Study Designs

  • Stephen P. Glasser


This chapter addresses some of the central concepts related to clinical research and what is meant by the strength of scientific evidence. We also begin to discuss the different clinical research designs along with their respective strengths and weaknesses.


Null Hypothesis Randomized Clinical Trial Statistical Hypothesis Research Hypothesis Passive Smoke 
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  1. 1.
  2. 2.
    Vickers AJ. Michael Jordan won’t accept the null hypothesis: notes on interpreting high P values. Medscape. 2006; 7(1).Google Scholar
  3. 3.
    The Null Logic of Hypothesis Testing.∼icc_cmf/cj_787/research6.doc
  4. 4.
    Blackstone. Cited in The Null Logic of Hypothesis Testing. 2 Bl. Com. C. 27, margin page 358, ad finem. Available at:∼icc_cmf/cj_787/research6.doc
  5. 5.
    Connolly HM, Crary JL, McGoon MD, et al. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med. Aug 28, 1997; 337(9):581–588.PubMedCrossRefGoogle Scholar
  6. 6.
    Cited in Sartwell P and Nathanson N. Epidemiologic Reviews. 1993.Google Scholar
  7. 7.
    Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and recurrent events trial investigators. N Engl J Med. Oct 3, 1996; 335(14):1001–1009.PubMedCrossRefGoogle Scholar
  8. 8.
    Doll R. Cohort studies: history of the method. II. Retrospective cohort studies. Soz Praventivmed 2001; 46(3):152–160.PubMedCrossRefGoogle Scholar
  9. 9.
    von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. Oct 16, 2007; 147(8):573–577.Google Scholar

Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Stephen P. Glasser
    • 1
  1. 1.Univesity of Alabama at Birmingham, Birmingham, AlabamaBirmingham

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