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Prostate Cancer: Detection and Monitoring Using Mitochondrial Mutations as a Biomarker

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General Methods and Overviews, Lung Carcinoma and Prostate Carcinoma

Part of the book series: Methods of Cancer Diagnosis, Therapy, and Prognosis ((HAYAT,volume 2))

Neoplastic transformation of the prostate gland is one of the leading causes of cancer morbidity and mortality among men in the industrialized world. As an ageassociated disease, the incidence of prostate cancer (PCa) will remain on the rise, mirroring the ageing Western population. Similar to other cancers, PCa is debilitating when diagnosed late. Surgical resection of organ-confined tumors is the best available curative method. Therefore, to obtain optimal cure, it is imperative that methods are developed that enable early detection and monitoring of this disease. Epigenetic nuclear gene silencing and alterations in both nuclear and mitochondrial genomes precede histopathologic changes indicative of PCa. Thus, sensitive assays that target the genetic signatures should help with early detection and successful treatment of PCa.

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Authors and Affiliations

  1. Genesis Genomics, Inc., 290 Munro Street, Ste. 1000, Thunder Bay, ON, P7A 7T1, Canada

    Gabriel D. Dakubo & Ryan L. Parr

  2. Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899

    John P. Jakupciak

Authors
  1. Gabriel D. Dakubo
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  2. Ryan L. Parr
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  3. John P. Jakupciak
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Corresponding author

Correspondence to Gabriel D. Dakubo .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Union, NJ, USA

    M. A. Hayat

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Dakubo, G.D., Parr, R.L., Jakupciak, J.P. (2008). Prostate Cancer: Detection and Monitoring Using Mitochondrial Mutations as a Biomarker. In: Hayat, M.A. (eds) General Methods and Overviews, Lung Carcinoma and Prostate Carcinoma. Methods of Cancer Diagnosis, Therapy, and Prognosis, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8442-3_32

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  • DOI: https://doi.org/10.1007/978-1-4020-8442-3_32

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-8441-6

  • Online ISBN: 978-1-4020-8442-3

  • eBook Packages: MedicineMedicine (R0)

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