That an oxidant can act either as a useful physiological messenger or a death signal is exemplified by the behaviour of blood treated with different ozone doses. Blood is an ideal tissue because is composed of plasma, which has a wealth of reductants, which can be easily measured before and after ozonation as well as cells able to cooperate to modulate the oxidant properties of ozone. Blood cells contain not only GSH and thioredoxin but enzymes able to promptly reduce oxidized compounds, thus restoring the initial antioxidant status. Our work over the last 16 years has identified important compounds generated ex vivo during the initial reaction of ozone with some plasma components and how these activate biochemical pathways with therapeutic effects after transfusion of the ozonated blood in the donor. We have shown that appropriate ozone doses are not toxic and elucidated the subtle interaction between the generated compounds and the antioxidant defences.
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Bocci, V. (2008). The Question of Balance: The Interaction Between Blood and Ozone. In: Valacchi, G., Davis, P.A. (eds) Oxidants in Biology. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8399-0_7
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