Connectivity Dependent Effects in Cognitive Neurodynamics of Mental Disorders

  • Hans Liljenström
  • Yuqiao Gu


Computational modeling was applied to investigate how cortical neurodynamics may depend on network connectivity. In particular, we study effects of pruning of cortical networks, which may be related to the onset of different mental disorders. In addition, we study changes in EEG pattern of depressed patients, following ECT (electroconvulsive therapy). The aim is to gain a better understanding of the neural mechanisms responsible for these changes, which include phase shifts in the EEG dynamics. This understanding is intended to provide clinical guidance, predicting ECT dose and response in depressed patients. Finally, we discuss the relevance of these results to clinical and experimental neuroscience and speculate on a link between neural instability and mental disorders.


Neurodynamics network connectivity EEG ECT pruning mental disorder computational models 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Saugstad, L.F.: The Maturational Theory of Brain Development and Cerebral Excitability in the Multifactorially Inherited Manic-depressive Psychosis and Schizophrenia. Int. J. Psychophysiol. 18 (1994) 189–203.PubMedCrossRefGoogle Scholar
  2. 2.
    Siekmeier, P.J., Hoffman, R.E.: Enhanced Semantic Priming in Schizophrenia: A Computer Model Based on Excessive Pruning of Local Connections in Association Cortex. British J. Psychiatry 180 (2002) 345–350.CrossRefGoogle Scholar
  3. 3.
    Beyer, J.L., Weiner, R.D., Glenn, M.D.: Electroconvulsive Therapy. Am. Psych. Press, Washington DC (1998).Google Scholar
  4. 4.
    Wahlund B, von Rosen D. ECT of Major Depressed Patients in Relation to Biological and Clinical Variables: A Brief Overview. Neuropsychopharmacology 28 (2003) S21–26.PubMedCrossRefGoogle Scholar
  5. 5.
    Gu, Y., Wahlund, B., Liljenström, H., von Rosen, D., Liang, H.: Analysis of Phase Shifts in Clinical EEG Evoked by ECT. Neurocomputing 65–66 (2005) 475–483.CrossRefGoogle Scholar
  6. 6.
    Liljenström, H.: Neural Stability and Flexibility - A Computational Approach. J. Neuropsychopharmac. 28 (2003) S64–S73.CrossRefGoogle Scholar
  7. 7.
    Gu, Y., Halnes, G., Liljenstrom, H., Wahlund, B.: A Cortical Network Model for Clinical EEG Data Analysis. Neurocomputing 58–60 (2004) 1187–1196.CrossRefGoogle Scholar
  8. 8.
    Gu, Y., Halnes, G., Liljenström, H., Liang, H., von Rosen, D., Wahlund, B.: Modelling ECT Effects by Connectivity Changes in Cortical Neural Networks. Neurocomputing 69 (2006) 1341–1347.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Hans Liljenström
    • 1
    • 2
  • Yuqiao Gu
    • 1
  1. 1.Department of Biometry and EngineeringSLUSE-75007 UppsalaSweden
  2. 2.Sweden Agora for BiosystemsSE- SigtunaSweden

Personalised recommendations