Abstract
We review the main results of a study on how the effects of cerebellar long-term depression are reflected in Purkinje cell spiking. An initial modeling study produced surprising results: when actual spike trains were simulated it was predicted that synaptic depression resulted in an increase of the spiking output. Subsequent collaboration with another team led to the confirmation of the main results using patch clamp recordings in in vitro cerebellar slices, which suggested additional modeling. A third team provided supporting data from in vivo cerebellar recordings. This group effort provides useful insights into ethical and professional issues concerning collaborations between modelers and experimentalists in neuroscience.
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Steuber, V., Mittmann, W., Hoebeek, F.E., Silver, R.A., De Zeeuw, C.I., Häusser, M., De Schutter, E.: Cerebellar LTD and Pattern Recognition by Purkinje Cells. Neuron 54 (2007) 121–136
Ito, M.: Cerebellar long-term depression: Characterization, signal transduction, and functional roles. Physiol. Rev. 81 (2001) 1143–1195
De Schutter, E., Bower, J.M.: An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. J. Neurophysiol. 71 (1994) 375–400
Steuber, V., De Schutter, E.: Long-term depression and recognition of parallel fibre patterns in a multi-compartmental model of a cerebellar Purkinje cell. Neurocomput. 38 (2001) 383–388
Shin, S.-L, Hoebeek, F.E., Schonewille, M., De Zeeuw, C.I., Aertsen, A., De Schutter E.: Regular temporal patterns in cerebellar Purkinje cell simple spike trains. PLoS One 2 (2007) e485
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Schutter, E.D., Steuber, V. (2008). A European Collaboration on Cerebellar LTD and Pattern Recognition. In: Wang, R., Shen, E., Gu, F. (eds) Advances in Cognitive Neurodynamics ICCN 2007. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8387-7_4
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DOI: https://doi.org/10.1007/978-1-4020-8387-7_4
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-8386-0
Online ISBN: 978-1-4020-8387-7
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