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Breast and Prostate Biopsies: Use of Optimized High-Throughput MicroRNA Expression for Diagnosis (Methodology)

  • Michael D. Mattie
  • Robert C. Getts
Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 1)

Recent technological advancements and methodologies have been developed to perform global analysis of tissue-specific ‘signatures’ of microRNAs in humans. The emerging view from such studies is that altered miRNA expression commonly occurs in a variety of cancers, which underscores the potential utility of miRNA profiling for diagnostic and prognostic applications. We present here a high-throughput methodology for miRNA profiling that is sufficiently sensitive for routine use on clinical specimens with limited starting material.

Keywords

Prostate Biopsy miRNA Profile MicroRNA Expression Collection Tube Sample Reservoir 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media B.V. 2008

Authors and Affiliations

  • Michael D. Mattie
    • 1
  • Robert C. Getts
    • 2
  1. 1.GlaxoSmithKlineResearch Triangle Park
  2. 2.Genisphere Inc.Hatfield

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