Skip to main content
SpringerLink
Log in
Book cover

Ultradian Rhythms from Molecules to Mind pp 391–411Cite as

Open Questions on Mind, Genes, Consciousness, and Behavior: The Circadian and Ultradian Rhythms of Art, Beauty, and Truth in Creativity

  • Chapter

Abstract

An earlier companion volume to this text ended with an epilogue on “The Unification Hypothesis of Chronobiology from Molecule to Mind” wherein we traced the evolution of life and mind as manifest in our circadian and ultradian psychobiology (Lloyd and Rossi, 1992). This chapter extends that broad scenario by reviewing the circadian and ultradian rhythms of gene expression, brain plasticity, and creative experience as we pursue the eternal verities of art, beauty, and truth in science as well as everyday life. This will be a highly speculative and lofty philosophical pursuit, which we will survey as a provocative series of “open questions” about mind, genes, consciousness, and behavior. We will explore our understanding of “the meaning of it all” by balancing the traditional reductionism of chronobiological research with the constructive approaches of the new in silico bioinformatic databases of functional genomics, neuroscience, medicine, and psychology. We will balance the traditional “Bottoms-Up Approach” of the physical and biological sciences with our “Top-Down Approach” for a unified understanding of the human condition from a deep chronobiological and psychobiological perspective.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aldrich, K., & Bernstein, D. (1987). The effect of time of day on hypnotizability. International Journal of Clinical & Experimental Hypnosis, 35, 141–145.

    Article  Google Scholar 

  • Balch, W., Morimoto, R., Dillin, A., Kelly, J. (2008). Adapting proteostasis for disease intervention. Science, 319, 916–919.

    Article  PubMed  Google Scholar 

  • Bird, A. (2007). Perceptions of epigenetics. Nature, 447, 396–398.

    Article  PubMed  Google Scholar 

  • Blagosklonny, M., and Pardee, A. (2002). Conceptual biology: Unearthing the gems. Nature, 416, 373.

    Article  PubMed  Google Scholar 

  • Buzsáki, G. (1996). The Hippocampo-Neocortical Dialogue. Cerebral Cortex, 6, 81–92.

    Article  PubMed  Google Scholar 

  • Buzsáki, G. (2006). Rhythms of the Brain. New York: Oxford University Press.

    Book  Google Scholar 

  • Cheung, M., Chavez, L., and Onuchic, J. (2004). The energy landscape for protein folding and possible connections to function. Polymer, 45, 547–555.

    Article  Google Scholar 

  • De Waele, R., Koenderink, A., and Polman, A. (2007). Tunable nanoscale localization of energy on plasmon particale arrays. Nano Letters, 7, 2004–2008.

    Article  Google Scholar 

  • Drosopoulos, S., Windau, E., Wagner U., and Born, J. (2007) Sleep enforces the temporal order in memory. PLoS ONE 2(4): e376. doi:10.1371 /journal. pone.0000376.

    Article  PubMed  Google Scholar 

  • Duchniewska, K., and Kokoszka, A. (2003). The protective mechanisms of the basic rest-activity cycle as an indirect manifestation of this rhythm in waking: Preliminary report. International Journal of Neuroscience, 113, 153–163.

    Article  PubMed  Google Scholar 

  • Feinberg, A. (2007). Phenotypic plasticity and the epigenetics of human disease. Nature, 447, 433–440.

    Article  PubMed  Google Scholar 

  • Fraser, P., and Blickmore, W. (2007). Nuclear organization of the genome and the potential for gene regulation. Nature, 447, 413–417.

    Article  PubMed  Google Scholar 

  • Goho, A. (2004). Gene screen: Ultrasensitive nanowires catch mutations. Science News, 165, 6.

    Article  Google Scholar 

  • Grimaldi, B., and Sassone-Corsi, P. (2007). Metabolic clockwork. Nature, 447, 386–387.

    Article  PubMed  Google Scholar 

  • Hahm, J., and Lieber, C. (2004). Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors. Nano Letters, 4(1), 51–54. doi: 10.1021/nl034853b.

    Article  Google Scholar 

  • Hahn, T., Sakmann, B., and Mehta, M. (2007). Differential responses of hippocampal subfields to cortical up-down states. Proceedings of the National Academy of Sciences of the United States of America, 104, 5169–5174.

    Article  PubMed  Google Scholar 

  • Hawkins, J., and Blakeslee, S. (2004). On Intelligence. New York: Owl Book/Holt.

    Google Scholar 

  • Hull, C. (1933/1968). Hypnosis and suggestibility. New York: Appleton-Century-Crofts.

    Google Scholar 

  • Ji, D., and Wilson, M. (2007). Coordinated memory replay in the visual cortex and hippocampus during sleep. Nature Neuroscience, 10, 100–107.

    Article  PubMed  Google Scholar 

  • Johnson, C. (1999). Fourty years of PRCs–what have we learned? Chronobiology International, 16, 711–743.

    Article  Google Scholar 

  • Jung, C. (1927). General Index: The Collected Works of C. G. Jung. Bollingen series, 20. Princeton, NJ: Princeton University Press.

    Google Scholar 

  • Jung, C. (1953). Psychology and Alchemy: The Collected Works of C. G. Jung. Bollingen series, 12. Princeton, NJ: Princeton University Press.

    Google Scholar 

  • Káli, S., and Dayan, P. (2004). Off-line replay maintains declarative memories in a model of hippocampal-neocortical interactions. Nature Neuroscience, 7, 286–294.

    Article  PubMed  Google Scholar 

  • Kamien, R. (2006). Music, an Appreciation. New York: McGraw-Hill.

    Google Scholar 

  • Lamb, J., Crawford, E., Peck, D., Modell, J., Blat, I., Wrobel, M., Lerner, J., Brunet, J., Subramanian, A., Ross, K., Reich, M., Hieronymus, H., Wei, G., Armstrong, S., Haggarty, S., Clemons, P., Wei, R., Carr, S., Lander, E., & Golub, T. (2006). The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease. Science, 313, 1929–1935.

    Article  PubMed  Google Scholar 

  • Levsky, J., Shenoy, S., Pezo, C., and Singer, R. (2002). Single-cell gene expression profiling. Science, 297, 836–840.

    Article  PubMed  Google Scholar 

  • Liu, C., Li, S., Liu, T., Borjigin, J., and Lin, J. (2007). Transcriptional coactivator PGC-1L integrates the mammalian clock and energy metabolism. Nature, 447, 477–481.

    Article  PubMed  Google Scholar 

  • Lin, L., Chen, H., Kuang, D., Wang, D., & Tsien, J. (2007). Neural encoding of the concept of nest in the mouse brain. Proceedings of the National Academy of Sciences USA, 104, 6066–6071.

    Article  Google Scholar 

  • Lisman, J. & Morris, G. (2001). Why is the cortex a slow learner? Nature, 411, 248–249.

    Article  PubMed  Google Scholar 

  • Lloyd, D. & Rossi, E. (Eds.) (1992). Ultradian Rhythms in Life Processes: An Inquiry into Fundamental Principles of Chronobiology and Psychobiology. New York: Springer-Verlag.

    Google Scholar 

  • Mehta, M. (2007). Cortico-hippocampal interaction during up-down states and memory consolidation. Nature Neuroscience, 10, 13–15.

    Article  PubMed  Google Scholar 

  • Orr, W., Hoffman, H., and Heggey, F. (1974). Ultradian rhythms in extended performance. Aerospace Medicine, 45, 995–1000.

    PubMed  Google Scholar 

  • Panda, S., Hogenesch, J., and Kay, S. (2002a). Circadian rhythms from flies to humans. Nature, 417, 329–335.

    Article  PubMed  Google Scholar 

  • Panda, S., Antoch, M., Miller, B., Su, A., Schook, A., Straume, M., Schultz, P., Kay, S., Takahashi, J., and Hogenesch, J. (2002b). Coordinated transcription of key pathways in the mouse by the circadian clock. Cell, 109, 307–320.

    Article  PubMed  Google Scholar 

  • Pavlov, I. (1927). Conditioned reflexes: an investigation of the physiological activity of the cerebral cortex. Anrep, G. (Trans.). Oxford: Oxford University Press.

    Google Scholar 

  • Pereira, A., Huddleston, D., Brickman, A., Sosunov, A., Hen, R., McKhann, G., Sloan, R., Gage, F., Brown, T., and Small, S. (2007). An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proceedings of the National Academy of Sciences, 104, 5638–5643.

    Article  Google Scholar 

  • Ribeiro, S., Simões, C., and Nicolelis, M. (2008). Genes, Sleep and Dreams. In Lloyd, D. and Rossi, E. (2008). Ultradian Rhythms from Molecules to Mind: a New Vision of Life. New York: Springer.

    Google Scholar 

  • Rosbash, M., & Takahashi, J. (2002). Circadian rhythms: the cancer connection. Nature, 420, 373–374.

    Article  PubMed  Google Scholar 

  • Rossi, E. (1986/1993). The Psychobiology of Mind-Body Healing: New Concepts of Therapeutic Hypnosis. New York: W. W. Norton.

    Google Scholar 

  • Rossi, E. (2002a). The Psychobiology of Gene Expression: Neuroscience and Neurogenesis in Therapeutic Hypnosis and the Healing Arts. New York: W. W. Norton.

    Google Scholar 

  • Rossi, E. (2002b). The psychosocial genomics of therapeutic hypnosis and psychotherapy. Sleep and Hypnosis: An International Journal of Sleep, Dream, and Hypnosis, 4(1), 26–38.

    Google Scholar 

  • Rossi, E. (2002c). A conceptual review of the psychosocial genomics of expectancy and surprise: Neuroscience perspectives about the deep psychobiology of therapeutic hypnosis. American Journal of Clinical Hypnosis, 45(2), 103–118.

    PubMed  Google Scholar 

  • Rossi, E. (2002d). Psychosocial genomics: Gene expression, neurogenesis, and human experience in mind-body medicine. Advances: In Mind-Body Medicine, 22–30.

    Google Scholar 

  • Rossi, E. (2003). Gene expression, neurogenesis, and healing: Psychosocial genomics of therapeutic hypnosis. American Journal of Clinical Hypnosis, 45(3), 197–216.

    PubMed  Google Scholar 

  • Rossi, E. (2004a). (Salvador Iannotti, Translator and Editor: Saiannot@tin.it,) Discorso Tra Geni [Italian]. A Discourse with Our Genes: The Psychosocial and Cultural Genomics of Therapeutic Hypnosis and Psychotherapy. Benevento, Italy: Editris SAS[available in Italian and English editions]. New York: Zeig, Tucker, Theisen.

    Google Scholar 

  • Rossi, E. (2004b). A bioinformatics approach to the psychosocial Genomics of therapeutic hypnosis. Hypnos, 31(1), 15–21.

    Google Scholar 

  • Rossi, E. (2005). (Laurent Carrer, Translator and Editor). Cinq essais de psychogénomique–exploration d’une nouvelle démarche scientifique axée sur l’interaction entre l’esprit et la molécule [Five Essays on Psychosocial Genomics: Exploration of a New Scientific Approach to the Interaction Between Mind and Molecule]. Encinitas, CA: Trance-lations.

    Google Scholar 

  • Rossi, E. (2007). The Breakout Heuristic: The New Neuroscience of Mirror Neurons, Consciousness and Creativity in Human Relationships: Selected Papers of Ernest Lawrence Rossi. Phoenix, AR: The Milton H. Erickson Foundation Press. office@erickson-foundation.org

  • Rossi, E. (2008). The neuroscience of therapeutic hypnosis, psychotherapy, and rehabilitation. In Rossi, E., Erickson-Klein, R. & Rossi, K., (Eds.), The Complete Works of Milton H. Erickson, M.D. Volume 1: The Nature of Hypnosis. Phoenix: The MHE Foundation Press.

    Google Scholar 

  • Rossi, E., and Cheek, D. (1988). Mind-Body Therapy: Ideodynamic Healing in Hypnosis. New York: W. W. Norton.

    Google Scholar 

  • Rossi, E., and Lippincott, B. (1992). The wave nature of being: Ultradian rhythms and mind-body communication. In Lloyd, D., and Rossi, E. (Eds.), Ultradian Rhythms in Life Processes: A Fundamental Inquiry into Chronobiology and Psychobiology. New York: Springer (pp. 371–402).

    Google Scholar 

  • Rossi, E., and Kleitman, N. (1992). The basic rest-activity cycle–32 years later: An interview with Nathaniel Kleitman. In Lloyd, D., and Rossi, E. (Eds.), Ultradian Rhythms in Life Processes: A Fundamental Inquiry into Chronobiology and Psychobiology. New York: Springer (pp. 303–306).

    Google Scholar 

  • Rossi, E. and Nimmons, D. (1991). The Twenty-Minute Break: The Ultradian Healing Response. Los Angeles, CA: Jeremy Tarcher, New York: Zeig, Tucker, Theisen.

    Google Scholar 

  • Rossi, E., Rossi, K., Yount, G., Cozzolino, M., and Iannotti, S. (2006). The bioinformatics of integrative medical insights: Proposals for an international psychosocial and cultural bioinformatics project. Integrated Medicine Insights. Open access on line: http://www.la-press.com/integmed.htm

  • Rossi, E., Erickson-Klein, R., and Rossi, K. (2008). The future orientation of constructive memory: An evolutionary perspective on therapeutic hypnosis and brief psychotherapy. American Journal of Clinical Hypnosis, 50(4), 341–347.

    Google Scholar 

  • Rossi, E., Rossi, K., Cozzolino, M., and Iannotti, S. (2007). Expectations of hypnosis future: A new neuroscience school of therapeutic hypnosis, psychotherapy, and rehabilitation. European Journal of Clinical Hypnosis, 7(3), 2–9.

    Google Scholar 

  • Sanders, S., and Mann, B. (1995). The effects of light, temperature, trance length and time of day on hypnotic depth. American Journal of Clinical Hypnosis, 37, 43–53.

    PubMed  Google Scholar 

  • Segal, E., Sirlin, C., Ooi, C., Adler, A., Gollub, J., Chen, X., Chan B., Matcuk, G., Barry, C., Chang, H., and Kuo, M. (2007). Decoding global gene expression programs in liver cancer by noninvasive imaging. Nature Biotechnology, 25, 675–680.

    Article  PubMed  Google Scholar 

  • Shono, M., Takasaki, M., Ito, Y., Muro, M., Iwasaka, and T., Sugimori, H. (2001). A new method to analyze basic rest-activity cycle. Psychiatry Clinical Neuroscience, 55, 169, 170.

    Article  Google Scholar 

  • Solomon, M. (2003). Late Beethoven. Los Angeles, CA: University of California Press.

    Google Scholar 

  • Storch, K., Lipan, O., Leykin, I., Viswanathan, N., Davis, F., Wong, W., and Weitz, C. (2002). Extensive and divergent circadian gene expression in liver and heart Nature, 417, 78–83.

    Article  PubMed  Google Scholar 

  • Stickgold, R., Roar Fosse, R., and Walker, M. (2007). Linking brain and behavior in sleep-dependent learning and memory consolidation. Proceedings of the National Academy of Sciences, 99, 16519–16521.

    Article  Google Scholar 

  • Talan, J. (2007). Calming the manic mind: Mutation in “Clock Gene”, which helps control body’s rhythm, linked to symptoms of mania in mice, humans. Brain in the News, Washington, DC: Dana Foundation (p. 5).

    Google Scholar 

  • Toni, N., Teng, E., Bushong, E., Aimone, J., Zhao, C., Consiglio, A., van Praag, H., Martone, M., Ellisman, M., and Gage, F. (2007). Synapse formation on neurons born in the adult hippocampus. Nature Neuroscience, doi:10.1038/nn1908, 1–9.

    Google Scholar 

  • Ueda, H., Chen, W., Adachi, A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S., Iino, M., Shigeyoshi, Y., and Hashimoto, S. (2002). A transcription factor response element for gene expression during circadian night. Nature, 418, 534–539.

    Article  PubMed  Google Scholar 

  • Unterweger, E., Lamas, J., and Bongartz, W. (1992). Heart-rate variability of high and low susceptible subjects during administration of the Stanford scale, Form C. In Bongartz, E. (Ed.), Hypnosis: 175 Years After Mesmer: Recent Developments in Theory and Application. Konstanz, Germany: Universitatsvergag.

    Google Scholar 

  • Van Hulst, N. (2007). Light in chains. Nature, 448, 141–142.

    Article  PubMed  Google Scholar 

  • Wallas, G. (1926). The Art of Thought. New York: Harcourt.

    Google Scholar 

  • Wilber, K. (1993). The spectrum of consciousness. 2nd Edition. Wheaton, IL: Quest Books.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. New Neuroscience School of Therepeutic Hypnosis and Psychotherapy, San Lorrenzo Maggiore, Italy

    E. L. Rossi & K. L. Rossi

  2. Ernest Rossi Foundation for Psychosocial Genomic Research, 125 Howard Avenue, Los Osos, USA

    E. L. Rossi & K. L. Rossi

Authors
  1. E. L. Rossi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. L. Rossi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Microbiology (BIOSI 1), Cardiff University, Main Building, Cardiff, CF10 3TL, Wales, UK

    David Lloyd

  2. 125 Howard Ave., Los Osos, CA, 93402, USA

    Ernest L. Rossi

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science + Business Media B.V

About this chapter

Cite this chapter

Rossi, E.L., Rossi, K.L. (2008). Open Questions on Mind, Genes, Consciousness, and Behavior: The Circadian and Ultradian Rhythms of Art, Beauty, and Truth in Creativity. In: Lloyd, D., Rossi, E.L. (eds) Ultradian Rhythms from Molecules to Mind. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8352-5_16

Download citation

Publish with us

Policies and ethics

Search

Navigation