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Part of the book series: World Class Parasites ((WCPA,volume 9))

Abstract

Toxoplasma gondii is a protozoan parasite of warm-blooded animals including humans. It has a worldwide distribution. Cats, including all felines, are its definitive hosts and excrete environmentally-resistant oocysts in their feces. Hosts become infected by ingesting food or drink contaminated with oocysts or by ingesting undercooked meat infected with T. gondii. It causes mental retardation and loss of vision in congenitally-infected children and abortion in livestock. This chapter describes life cycle, epidemiology, diagnosis, and prevention of T. gondii.

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References

  • Aramini, J.J., C. Stephen, and J.P. Dubey. 1998. Toxoplasma gondii in Vancouver Island cougars (Felis concolor vancouverensis): serology and oocyst shedding. Journal of Parasitology 84: 438–440.

    Article  PubMed  CAS  Google Scholar 

  • —, —, —, C. Engelstoft, H. Schwantje, and C.S. Ribble. 1999. Potential contamination of drinking water with Toxoplasma gondii oocysts. Epidemiology and Infection 122: 305–315.

    Article  PubMed  Google Scholar 

  • Aspinall, T.V., D. Marlee, J.E. Hyde, and P.F.G. Sims. 2002. Prevalence of Toxoplasma gondii in commercial meat products as monitored by polymerase chain reaction — food for thought? International Journal for Parasitology 32: 1193–1199.

    Article  PubMed  Google Scholar 

  • Assadi-Rad, A.M., J.C. New, and S. Patton. 1995. Risk factors associated with transmission of Toxoplasma gondii to sows kept in different management systems in Tennessee. Veterinary Parasitology 57: 289–297.

    Article  PubMed  CAS  Google Scholar 

  • Bahia-Oliveira, L.M.G., J.L. Jones, J. Azevedo-Silva, C.C.F. Alves, F. Orefice, and D.G. Addiss. 2003. Highly endemic, waterborne toxoplasmosis in North Rio de Janeiro State, Brazil. Emerging Infectious Diseases 9: 55–62.

    PubMed  Google Scholar 

  • Bowie, W.R., A.S. King, D.H. Werker, J.L. Isaac-Renton, A. Bell, S.B. Eng, and S.A. Marion. 1997. Outbreak of toxoplasmosis associated with municipal drinking water. Lancet 350: 173–177.

    Article  PubMed  CAS  Google Scholar 

  • Claus, G.E., E. Christie, and J.P. Dubey. 1977. Prevalence of Toxoplasma antibody in feline sera. Journal of Parasitology 63: 266.

    Article  PubMed  CAS  Google Scholar 

  • Cole, R.A., D.S. Lindsay, D.K. Howe, C.L. Roderick, J.P. Dubey, N.J. Thomas, and L.A. Baeten. 2000. Biolgical and molecular characterizations of Toxoplasma gondii strains obtained from southern sea otters (Enhydra lutris nereis). Journal of Parasitology 86: 526–530.

    Article  PubMed  CAS  Google Scholar 

  • Cook, A.J.C., R.E. Gilbert, W. Buffolano, J. Zufferey, E. Petersen, P.A. Jenum, W. Foulon, A.E. Semprini, and D.T. Dunn. 2000. Sources of toxoplasma infection in pregnant women: European multicentre case-control study. British Medical Journal 321: 142–147.

    Article  PubMed  CAS  Google Scholar 

  • Davies, P.R., W.E.M. Morrow, J. Deen, H.R. Gamble, and S. Patton. 1998. Seroprevalence of Toxoplasma gondii and Trichinella spiralis in finishing swine raised in different production systems in North Carolina, USA. Preventive Veterinary Medicine 36: 67–76.

    Article  PubMed  CAS  Google Scholar 

  • DeFeo, M.L., J.P. Dubey, T.N. Mather, and R.C. RhodesIII. 2002. Epidemiology investigation of seroprevalence of antibodies to Toxoplasma gondii in cats and rodents. American Journal of Veterinary Research. 63: 1714–1717.

    Article  PubMed  Google Scholar 

  • Dubey, J.P. 1976. Re-shedding of Toxoplasma oocysts by chronically infected cats. Nature 262: 213–214.

    Article  PubMed  CAS  Google Scholar 

  • —. 1994. Toxoplasmosis. Journal of the American Veterinary Medical Association 205: 1593–1598.

    PubMed  CAS  Google Scholar 

  • —. 1995. Duration of immunity to shedding of Toxoplasma gondii oocysts by cats. Journal of Parasitology 81: 410–415.

    Article  PubMed  CAS  Google Scholar 

  • —. 1996. Infectivity and pathogenicity of Toxoplasma gondii oocysts for cats. Journal of Parasitology 82: 957–960.

    Article  PubMed  CAS  Google Scholar 

  • —. 1998. Refinement of pepsin digestion method for isolation of Toxoplasma gondii from infected tissues. Veterinary Parasitology 74: 75–77.

    Article  PubMed  CAS  Google Scholar 

  • —. 2001. Oocyst shedding by cats fed isolated bradyzoites and comparision of infectivity of bradyzoites of the VEG strain Toxoplasma gondii to cats and mice. Journal of Parasitology 87: 215–219.

    Article  PubMed  CAS  Google Scholar 

  • —. 2002a. A review of toxoplasmosis in wild birds. Vèterinary Parasitology 106: 121–153.

    Article  PubMed  CAS  Google Scholar 

  • —. 2002b. Tachyzoite-induced life cycle of Toxoplasma gondii in cats. Journal of Parasitology 88: 713–717.

    Article  PubMed  CAS  Google Scholar 

  • —, and C.P. Beattie. 1988. Toxoplasmosis of animals and man. CRC Press, Boca Raton, Florida 220p.

    Google Scholar 

  • —, and J.L. Carpenter. 1993a. Neonatal toxoplasmosis in littermate cats. Journal of the American Veterinary Medical Association 203: 1546–1549.

    Google Scholar 

  • —. and — 1993b. Histologically confirmed clinical toxoplasmosis in cats — 100 cases (1952–1990). Journal of the American Veterinary Medical Association 203: 1556–1566.

    Google Scholar 

  • Dubey JP., and J.K. Frenkel. 1972. Cyst-induced toxoplasmosis in cats. Journal of Protozoology 19: 155–177.

    PubMed  CAS  Google Scholar 

  • — and —. 1976. Feline toxoplasmosis from acutely infected mice and the development of Toxoplasma cysts. Journal of Protozoology 23: 537–546.

    Google Scholar 

  • — and I. Johnstone. 1982. Fatal neonatal toxoplasmosis in cats. Journal of the American Animal Hospital Association 18: 461–467.

    Google Scholar 

  • — and C.A. Kirkbride. 1989. Economic and public health considerations of congenital toxoplasmosis in lambs. Journal of the American Veterinary Medical Association 195: 1715–1716.

    PubMed  Google Scholar 

  • — and K. Odening. 2001. Toxoplasmosis and related infections. Samuel. W.M., M.J. Pybus, and A.A. Kocan, eds. Parasitic Diseases of Wild Mammals. Iowa State University Press, Ames, 478–519.

    Google Scholar 

  • — and D.W. Thayer. 1994. Killing of different strains of Toxoplasma gondii tissue cysts by irradiation under defined conditions. Journal of Parasitology 80: 764–767.

    Article  PubMed  Google Scholar 

  • —, J.L. Carpenter, M.J. Topper, and A. Uggla. 1989. Fatal toxoplasmosis in dogs. Journal of the American Animal Hospital Association 25: 659–664.

    Google Scholar 

  • —, E. Christie, and P.W. Pappas. 1977. Characterization of Toxoplasma gondii from the feces of naturally infected cats. Journal of Infectious Diseases 136: 432–435.

    PubMed  Google Scholar 

  • —, H.R. Gamble, D. Hill, C. Sreekumar, S. Romand, and P. Thulliez. 2003. High prevalence of viable Toxoplasma gondii infection in market weight pigs from a farm in Massachusetts. Journal of Parasitology 88: 1234–1238.

    Google Scholar 

  • —, D.H. Graham, C.R. Blackston, T. Lehmann, S.M. Gennari, A.M.A. Ragozo, S.M. Nishi, S.K. Shen, O.C.H. Kwok, D.E. Hill, and P. Thulliez. 2002. Biological and genetic characterisation of Toxoplasma gondii isolates from chickens (Gallus domesticus) from São Paulo, Brazil: Unexpected findings. International Journal for Parasitology 32: 99–105.

    Article  PubMed  Google Scholar 

  • —, J.G. Humphreys, and P. Thulliez. 1995a. Prevalence of viable Toxoplasma gondii tissue cysts and antibodies to T. gondii by various serologic tests in black bears (Ursus americanus) from Pennsylvania. Journal of Parasitology 81: 109–112.

    PubMed  Google Scholar 

  • —, A.W. Kotula, A. Sharar, C.D. Andrews, and D.S. Lindsay. 1990. Effect of high temperature on infectivity of Toxoplasma gondii tissue cysts in pork. Journal of Parasitology 76: 201–204.

    Article  PubMed  Google Scholar 

  • —, J.C. Leighty, V.C. Beal, W.R. Anderson, C.D. Andrews, and P. Thulliez. 1991. National seroprevalence of Toxoplasma gondii in pigs. Journal of Parasitology 77: 517–521.

    PubMed  Google Scholar 

  • —, J.K. Lunney, S.K. Shen, O.C.H. Kwok, D.A. Ashford, and P. Thulliez. 1996. Infectivity of low numbers of Toxoplasma gondii oocysts to pigs. Journal of Parasitology 82: 438–443.

    Article  PubMed  Google Scholar 

  • —, W.J.A. Saville, J.F. Stanek, and S.M. Reed. 2002. Prevalence of Toxoplasma gondii antibodies in domestic cats from rural Ohio. Journal of Parasitology 88: 802–803.

    PubMed  Google Scholar 

  • —, P. Thulliez, and E.C. Powell. 1995b. Toxoplasma gondii in Iowa sows: Comparison of antibody titers to isolation of T. gondii by bioassays in mice and cats. Journal of Parasitology 81: 48–53.

    Article  PubMed  Google Scholar 

  • —, R.M. Weigel, A.M. Siegel, P. Thulliez, U.D. Kitron, M.A. Mitchell, A. Mannelli, N.E. Mateus-Pinilla, S.K. Shen, O.C.H. Kwok, and K.S. Todd. 1995c. Sources and reservoirs of Toxoplasma gondii infection on 47 swine farms in Illinois. Journal of Parasitology 81: 723–729.

    Article  PubMed  Google Scholar 

  • Foulon W., A. Naessens, and D. Ho-Yen. 2000. Prevention of congenital toxoplasmosis. Journal of Perinatal Medicine 28: 337–345.

    Article  PubMed  CAS  Google Scholar 

  • Frenkel, J.K. 1973. Toxoplasmosis: parasite life cycle, pathology and immunology. Hammond, D.M., and P.L. Long, eds. The Coccidia. Eimeria, Isospora, Toxoplasma and Related Genera. University Park Press, Baltimore, Maryland, 343–410.

    Google Scholar 

  • —, J.P. Dubey, and N.L. Miller. 1970. Toxoplasma gondii in cats: fecal stages identified as coccidian oocysts. Science 167: 893–896.

    Article  PubMed  Google Scholar 

  • Freyre, A., J.P. Dubey, D.D. Smith, and J.K. Frenkel. 1989. Oocyst-induced Toxoplasma gondii infections in cats. Journal of Parasitology 75: 750–755.

    Article  PubMed  CAS  Google Scholar 

  • —, J. Falcon, J. Berdie, J.C. Cruz, V. de Oliviera, and I. Sampaio. 1981. Estudio inicial del huesped definitivo de la toxoplasmosis en Montevideo. Annali della Facolta di Medicina Veterinaria di Uruquay 18: 77–88.

    Google Scholar 

  • Gamble, H.R., R.C. Brady, and J.P. Dubey. 1999. Prevalence of Toxoplasma gondii infection in domestic pigs in the New England states. Veterinary Parasitology 82: 129–136.

    Article  PubMed  CAS  Google Scholar 

  • Garrido, A.J., J., I. Cour Boveda, A.M. Berzosa Aguilar, and J. Pareja Miralles. 1972. Estudios sobre la epidemiología de la toxoplasmosis. La infección del gato domestico en los alrededores de Madrid. Encuestas serólogica y coproparasitologica. Medicina Tropical 48: 24–39.

    Google Scholar 

  • Grover, C.M., P. Thulliez, J.S. Remington, and J.C. Boothroyd. 1990. Rapid prenatal-diagnosis of congenital Toxoplasma infection by using Polymerase Chain Reaction and amniotic fluid. Journal of Clinical Microbiology 28: 2297–2301.

    PubMed  CAS  Google Scholar 

  • Isaac-Renton J., W.R. Bowie, A. King, G.S. Irwin, C.S. Ong, C.P. Fung, M.O. Shokeir, and J.P. Dubey. 1998. Detection of Toxoplasma gondii oocysts in drinking water. Applied and Enviromental Microbiology 64: 2278–2280.

    CAS  Google Scholar 

  • Ito, S., K. Tsunoda, H. Nishikawa, and T. Matsui. 1974. Small type of Isospora bigemina. Isolation from naturally infected cats and relations with _Toxoplasma oocyst. National Institute of Animal Health Quarterly 14: 137–144.

    PubMed  CAS  Google Scholar 

  • Jacobs, L., and M.L. Melton. 1966. Toxoplasmosis in chickens. Journal of Parasitology 52: 1158–1162.

    Article  PubMed  CAS  Google Scholar 

  • —, J.S. Remington, and M.L. Melton. 1960. A survey of meat samples from swine, cattle, and sheep for the presence of encysted Toxoplasma. Journal of Parasitology 46: 23–28.

    Article  PubMed  CAS  Google Scholar 

  • Jakob-Hoff, R.M., and J.D. Dunsmore. 1983. Epidemiological aspects of toxoplasmosis in southern Western Australia. Australian Veterinary Journal 60: 217–218.

    Article  PubMed  CAS  Google Scholar 

  • Janitschke, K., and D. Kuhn. 1972. Toxoplasma-Oozysten im Kot naturlich infizierter Katzen. Berliner und Münchener Tierärztliche Wochenschrift 85: 46–47.

    PubMed  CAS  Google Scholar 

  • Jauregui, LH., J. Higgins, D. Zarlenga, J.P. Dubey, and J.K. Lunney, 2001. Development of a real-time PCR assay for the detection of Toxoplasma gondii in pig and mouse tissues. Journal of Clinical Microbiology 39: 2065–2071.

    Article  PubMed  CAS  Google Scholar 

  • Kotula, A.W., J.P. Dubey, A.K. Sharar, C.D. Andrew, S.K. Shen, and D.S. Lindsay. 1991. Effect of freezing on infectivity of Toxoplasma gondii tissue cysts in pork. Journal of Food Protection 54: 687–690.

    Google Scholar 

  • Lindsay DS., B.L. Blagburn, J.P. Dubey, and W.H. Mason. 1991. Prevalence and isolation of Toxoplasma gondii from white-tailed deer in Alabama. Journal of Parasitology 77: 62–64.

    Article  PubMed  CAS  Google Scholar 

  • Lopez, A., V.J. Dietz, M. Wilson, T.R. Navin, and J.L. Jones. 2000. Preventing congenital toxoplasmosis. Morbidity and Mortality Weekly Report 49: 59–75.

    CAS  Google Scholar 

  • Nery-Guimaraes, F., and H.A. Lage. 1973. Producao irregular e inconstante de oocistos pela ministracao de cistos de “itToxoplasma gondii” Nicolle & Manceaux, 1909, em gatos. Memorias do Institute Oswaldo Cruz 71: 157–167.

    Google Scholar 

  • Pampiglione, S., G. Poglayen, B. Arnone, and F. de Lalia. 1973. Toxoplasma gondii oocysts in the faeces of naturally infected cat. British Medical Journal 2: 306

    Article  PubMed  CAS  Google Scholar 

  • Patton, S., J. Zimmerman, T. Roberts, C. Faulkner, V. Diderrich, A. Assadi-Rad, P. Davies, and J. Kliebenstein. 1996. Seroprevalence of Toxoplasma gondii in hogs in the National Animal Health Monitoring System (NAHMS). Journal of Eukaryotic Microbiology 43: 121S

    Article  PubMed  CAS  Google Scholar 

  • Remington, J.S., R. McLeod, and G. Desmonts. 1995. Toxoplasmosis. Remington. J.S., and J.O. Klein, eds. Infectious diseases of the fetus and newborn infant. 4th edition: Saunders Company, Philadelphia, 140–267.

    Google Scholar 

  • —. 1968. Toxoplasmosis and congenital infection. Birth Defects 4: 49–56.

    Google Scholar 

  • Rifaat, M.A., M.S. Arafa, M.S.M. Sadek, N.T. Nasr, M.E. Azab, W. Mahmoud, and M.S. Khalil. 1976. Toxoplasma infection of stray cats in Egypt. Journal of Tropical Medicine and Hygiene 79: 67–70.

    PubMed  CAS  Google Scholar 

  • Ruiz, A., and J.K. Frenkel. 1980a. Intermediate and transport hosts of Toxoplasma gondii in Costa Rica. American Journal of Tropical Medicine and Hygiene 29: 1161–1166.

    PubMed  CAS  Google Scholar 

  • —, and —. 1980b. Toxoplasma gondii in Costa Rican cats. American Journal of Tropical Medicine and Hygiene 29: 1150–1160.

    Google Scholar 

  • Smith, K.E., J.J. Zimmerman, S. Patton, G.W. Beran, and J.T. Hill. 1992. The epidemiology of toxoplasmosis on Iowa swine farms with an emphasis on the roles of free-living mammals. Veterinary Parasitology 42: 199–211.

    Article  PubMed  CAS  Google Scholar 

  • Tenter, A.M., A.R. Heckeroth, and L.M. Weiss. 2000. Toxoplasma gondii: from animals to humans. International Journal for Parasitology 30: 1217–1258.

    Article  PubMed  CAS  Google Scholar 

  • Varga, I. 1982. Adatok a Toxoplasma gondii oocisztáinak budapesti macskák bélsarában és cisztáinak vágóhídi sertésekben észlelt gyakoriságához. Magyar Allatorvosok Lapja 37: 733–736.

    Google Scholar 

  • Wallace, G.D. 1973. The role of the cat in the natural history of Toxoplasma gondii. American Journal of Tropical Medicine and Hygiene 22: 313–322.

    PubMed  CAS  Google Scholar 

  • Warnekulasuriya, M.R., J.D. Johnson, and R.E. Holliman. 1998. Detection of Toxoplasma gondii in cured meats. International Journal of Food Microbiology 45: 211–215.

    Article  PubMed  CAS  Google Scholar 

  • Weigel, R.M., J.P. Dubey, A.M. Siegel, D. Hoefling, D. Reynolds, L. Herr, U.D. Kitron, S.K. Shen, P. Thulliez, R. Fayer, and T.S. Todd. 1995. Prevalence of antibodies to Toxoplasma gondii in Illinois swine in 1992. Journal of the American Veterinary Medical Association 206: 1747–1751.

    PubMed  CAS  Google Scholar 

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Dubey, J.P., Lindsay, D.S. (2004). Biology of Toxoplasma Gondii in Cast and Other Animals. In: Lindsay, D.S., Weiss, L.M. (eds) Opportunistic Infections: Toxoplasma, Sarcocystis, and Microsporidia. World Class Parasites, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4020-7846-0_1

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