Abstract
Adoptive immunotherapy of cancer involving activated cells of the immune system has been used on a extended basis in clinical oncology. Randomized studies showed that the combination of IL-2 with LAKs was most effective as compared with the IL-2 therapy alone. Despite the fact that the immunotherapy basic research is focused on melanoma, renal cancer, colorectal cancer and lymphomas, there are published data related to an effective use of IL-2/LAK-therapy in patients with other localizations. Adminstration of IL-2 and LAKs for effusion forms of cancer led to clinical effects in 88–94% of cases. A maximum cytoreducation of tumor is an additional way to enhance the efficacy of immunotherapy; it ensures the establishment of maximum correlation between tumor cells and killers. A combination of methods for activation of specific and non-specific immunity should be regarded as the most promising trend in the development of anti-tumor biotherapy. A promising approach in immunotherapy involves simultaneous treatment with LAKs and DCs that can stimulate both innate and adaptive anti-tumor immunity.
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Shubina, I.Z., Demidov, L.V., Chikileva, I.O., Lebedinskaya, O.V., Kiselevsky, M.V. (2008). LAK immunotherapy in clinical studies. In: Kiselevsky, M.V. (eds) Atlas Effectors of Anti-Tumor Immunity. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6931-4_7
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DOI: https://doi.org/10.1007/978-1-4020-6931-4_7
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