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Atlas Effectors of Anti-Tumor Immunity pp 81–99Cite as

Natural killer T (NKT) cells: Immunophenotype, functional characteristics and significance in clinical practice

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Abstract

Natural killer T cells are lymphocytes that express both T-cell and natural killer-cell markers. Natural killer T cells are found in parenchymal organs such as liver, lungs, spleen etc and a small number are found in peripheral blood. Natural killer T cells comprise a significant part of leukocyte infiltrates that occur in liver and other organs of patients with cancer or infectious diseases. These cells have a large impact on the functional activity of effectors of anti-tumor and anti-infectious immunity.

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Author information

Authors and Affiliations

  1. Department of Histology Embryology and Cytology, EA Vagner Perm Medical Academy, Perm, Russia

    Olga V. Lebedinskaya

  2. II Metchnikov Research Institute of Vaccines and Serum Laboratory of Therapeutic Vaccines Moscow, Russia

    Nelly K. Akchmatova

  3. Laboratory of Cell Immunity, NN Blokhin Russian Cancer Research Center RAMS, Moscow, Russia

    Irina O. Chikileva, Irina Zh. Shubina & Mikhail V. Kiselevsky

Authors
  1. Olga V. Lebedinskaya
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  2. Nelly K. Akchmatova
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  3. Irina O. Chikileva
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  4. Irina Zh. Shubina
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  5. Mikhail V. Kiselevsky
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Editor information

Editors and Affiliations

  1. Laboratory of Cell Immunity NN Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe shosse 24, Moscow, Russia 115478

    Mikhail V. Kiselevsky

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Lebedinskaya, O.V., Akchmatova, N.K., Chikileva, I.O., Shubina, I.Z., Kiselevsky, M.V. (2008). Natural killer T (NKT) cells: Immunophenotype, functional characteristics and significance in clinical practice. In: Kiselevsky, M.V. (eds) Atlas Effectors of Anti-Tumor Immunity. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6931-4_6

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