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CD8+ CD57+ T cells in tumor immunology

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Atlas Effectors of Anti-Tumor Immunity

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Abstract

The proportion of human peripheral blood CD8+ T cells that express CD57 is lower at birth but increases with age as well as in patients with several pathologies such as the human immunodeficiency virus infection (HIV), cytomegalovirus infection (CMV), myeloma multiple, colorectal cancer and gastric cancer. This T cell subset has been shown to be an effector phenotype characterized by IFN-γ production as well as being an important perforin and granzyme-A expression. It has been hypothesized that this results from continuous stimulation, however, this phenotype may be due to direct tumoral effects on CD8+ T cells. CD8+CD57+ T cells have been shown to infiltrate tumors in different stages, suggesting that they play a role in tumor immunology. In this chapter we analyze some basic aspects about how CD8+CD57+ T cells behave in tumor immunology.

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Author information

Authors and Affiliations

  1. Research Unit, Biochemistry Department, National Institute of Respiratory Diseases, Calzada de Tlalpan 4502, Col. Sección XVI, Delegación Tlalpan, Mexico D.F

    María I. Sada-Ovalle

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  1. María I. Sada-Ovalle
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Editors and Affiliations

  1. Laboratory of Cell Immunity NN Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe shosse 24, Moscow, Russia 115478

    Mikhail V. Kiselevsky

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Sada-Ovalle, M.I. (2008). CD8+ CD57+ T cells in tumor immunology. In: Kiselevsky, M.V. (eds) Atlas Effectors of Anti-Tumor Immunity. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6931-4_5

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