The key concepts of industrial process design are discussed. Two industrial synthesis of 7ACA and Erlotinib hydrochloride centred on the use of enzymatic and organometallic catalysis are described.
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References
Cabri, W. and Di Fabio, R., From Bench to Market. The Evolution of Chemical Synthesis from Discovery to Industrial Production. Oxford University Press, Oxford, 2000.
Anastas, P.T. and Warner, J.C., Green Chemistry Theory and Practice. Oxford University Press, Oxford, 1998.
Mannan, S (ed.) Lee’s Loss Prevention in the Process Industries. Elsevier, New York, 2005.
Sheldon, R.A., Chemtech 1994, 38.
Sawada, A., Yokokura, T., and Miyasaka, T., Ann. NY Acad. Sci. 1994, 14.
Francalanci, F., Cabri, W., DeBernardinis, S., Penco, S., Santi, R., and Noels, A.F., Metal Promoted Selectivity in Organic Synthesis. Kluwer Academic, The Netherlands, 1991, p. 207.
Cabri, W., Verga, R., Cambiaghi, S., and Bernasconi, E., La Chimica e L’industria 1999, 81, 461.
Cabri, W., Roletto, J. Olmo, S., Fonte, P., Ghetti, P., Songia, S., Mapelli, E., Alpegiani, M., and Paissoni, P., Org. Proc. Res. Dev. 2006 (to be published).
Adams, C., Chemistry Today 2004, 41.
Brotzu, G., Lavori dell’Istituto D’Igiene di Cagliari 1948, 6.
Abrahams, E.P., 50 Years of Penicillin Application 1991, Keinkauf, H. and von Duren, H. (eds.), Public Ltd., Czech Republic, pp. 7–23.
Loder, B., Newton, G.G.F., and Abrham, E.P., Biochem. J. 1961, 79, 408.
Morin, R.B., Jackson, B.G., Flynn, E.H., and Roeske, R.W., J. Am. Chem. Soc. 1962, 84, 3400.
Politino, M., Tonzi, S.M., Burnett, W.V., Romancik, G., and Usher, J., Appl. Environ. Microb. 1997, 63, 4807.
Shur, R.C.; Arnold, R.D., US5747498 (filed 28 May 1996).
Sonogashira, K., Tohda, Y., and Hagihara, N., Tetrahedron Lett. 1975, 4477.
(a) Lau, K.S.Y.; Boshan, R.H., US4465833 (filed 15 October 1980). (b) Austin, W.B.; Bilow, N., Kelleghan, W.J., and Lau, K.S.Y., J. Org. Chem. 1981, 46, 2280.
(a) FeSO4 heptahydrate Bilow, N., Landis, A.L., and Miller, L.J., US3845018. (b) NaHSO3 or Zn/NH4OH Kovar, R.F.; Arnold, F.E. US3975444 (filed 19 May 1975). (c) Zn/NH4OH Buravoy, A. and Critchley, J.P., Tetrahedron 1959, 340.
Hydrogenation Catalyst: (a) RuCl3/Al2O3: Onopchenko, A., Sabourin, E.T., and Selwitz, C.M., US4139561 (filed 27 February 1978); (b) RuS2 Onopchenko, A., Sabourin, E.T., and Selwitz, C.M., US4215226 (filed 6 November 1978) and Onopchenko, A., Sabourin, E.T., and Selwitz, C.M., J. Org. Chem. 1979, 44, 1233; (c) CoSx Onopchenko, A., Sabourin, E.T., and Selwitz, C.M., J. Org. Chem. 1979, 44, 3671.
Cabri, W. and Oldani, E., US5902902 (filed 18 February 1998).
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Cabri, W. (2008). Industrial Synthesis Design with Low Environmental Impact in the Pharma Industry. In: Mordini, A., Faigl, F. (eds) New Methodologies and Techniques for a Sustainable Organic Chemistry. NATO Science Series II: Mathematics, Physics and Chemistry, vol 246. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6793-8_6
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DOI: https://doi.org/10.1007/978-1-4020-6793-8_6
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