The previous chapters have described what cancer genes are and how they are acquired. But what do cancer genes do? How do the inactivation of tumor suppressor genes and activation of proto-oncogenes alter cell clones so that they evolve into cancers? The answer to this question has been revealed by the functional analysis of the proteins encoded by cancer genes and their wild-type counterparts. Cancer genes populate cellular pathways that control cellular proliferation and cell death.
KeywordsEpidermal Growth Factor Receptor Fanconi Anemia MDM2 Protein Receptor Protein Tyrosine Kinase Cytoplasmic Tyrosine Kinase
Unable to display preview. Download preview PDF.