Rodent Models of Oxygen-Induced Retinopathy

  • Susan E. Yanni
  • Gary W. McCollum
  • John S. Penn


Retinopathy of prematurity (ROP), a condition affecting premature infants, is characterized by pathological ocular angiogenesis, or retinal neovasculariztion (NV). Much of what is known about the development of the retinal vasculature and the progression of ROP has been acquired through the use of animal models of oxygen-induced retinopathy (OIR), which approximate ROP. Animal models of OIR have provided a wealth of information regarding the cellular and molecular pathogenesis of ROP. This information has contributed to a better understanding of other, non-ocular, neovascular conditions. The aim of this chapter is to explore the significance of the two most prevalent animal models of OIR, the mouse and the rat.


Vascular Endothelial Cell Growth Factor Vascular Endothelial Cell Growth Factor mRNA Vascular Endothelial Cell Growth Factor Retinal Vasculature Retinal Neovascularization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Susan E. Yanni
    • 1
  • Gary W. McCollum
    • 2
  • John S. Penn
    • 1
    • 2
  1. 1.Departments of Cell & Developmental BiologyVanderbilt University School of MedicineNashville
  2. 2.Ophthalmology and Visual SciencesVanderbilt University School of MedicineNashville

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