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Eph Receptor Tyrosine Kinases: Modulators of Angiogenesis

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Retinal and Choroidal Angiogenesis

Abstract

Angiogenesis, or the outgrowth of new sprouts from pre-existing vessels, involves a complex cascade of events. Among the diverse array of molecules involved in angiogenesis, receptor tyrosine kinases (RTKs) have emerged as critical mediators of neovascularization. This review will focus on the youngest family of essential vascular RTKs, the Eph receptors, and ephrins, their corresponding ligands. We will summarize our current understanding of Eph/ephrin function in vascular remodeling during embryogenesis and in neovascularization and tumorigenesis in adult tissues.

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Authors and Affiliations

  1. Department of Medicine Division of Rheumatology, Vanderbilt University Vanderbilt University School of Medicine, Nashville, Tennessee

    Jin Chen & Dana Brantley-Siders

  2. Department of Cancer Biology, Vanderbilt University Vanderbilt University School of Medicine, Nashville, Tennessee

    Jin Chen

  3. Department of Cell and Developmental Biology, Vanderbilt University Vanderbilt University School of Medicine, Nashville, Tennessee

    Jin Chen

  4. Department of Ophthalmology and Visual Sciences, Vanderbilt University Vanderbilt University School of Medicine, Nashville, Tennessee

    John S. Penn

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  1. Jin Chen
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  2. Dana Brantley-Siders
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  3. John S. Penn
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Editors and Affiliations

  1. Vanderbilt University School of Medicine, Nashville, TN, U.S.A

    J.S. Penn

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Chen, J., Brantley-Siders, D., Penn, J.S. (2008). Eph Receptor Tyrosine Kinases: Modulators of Angiogenesis. In: Penn, J. (eds) Retinal and Choroidal Angiogenesis. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6780-8_11

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