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Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response pp 21–32Cite as

Cell adhesion and invasion during secondary tumor formation: interactions between tumor cells and host organs

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Part of the book series: Cancer Growth and Progression ((CAGP,volume 11))

Abstract

To form clinically evident metastases, the main cause of death in cancer patients, cancer cells must complete a highly complex series of steps called the metastatic cascade. This includes local invasion, intravasation, transport in the circulation, adhesion and extravasation, survival, proliferation and angiogenesis. Since failure to complete any one of these steps results in metastatic failure, understanding the steps of the metastatic cascade may allow us to develop new therapeutic approaches for the treatment of cancer. Here we review the role of specific tumor cell (TC) adhesion and migration processes in organ-selective metastases formation. TC adhesion in the microvasculature of host organs is a specific and highly regulated process. Important adhesion molecules are: selectins in TC-endothelial cell adhesion and integrins in TC–extracellular matrix interactions. Defined expression of adhesion molecules and their corresponding ligands can govern this non-random process of organ-selective metastasis formation. Once TC adhesion in the microcirculation occurs, early extravasation of TCs, which is regulated by chemotactic stimuli of growth factors and/or chemokines in an organ-specific manner, can be observed.

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References

  • Adachi M, Taki T, Ieki Y, Huang C, Higashiyama M, Miyake M (1996) Correlation of KAI1/CD82 gene expression with good prognosis in patients with non-small cell lung cancer. Cancer Res 56:1751–1755.

    PubMed  CAS  Google Scholar 

  • Alexiou D, Karayiannakis AJ, Syrigos KN, Zhar A, Sekara E, Michail P, Rosenberg T, Diamantis T (2003) Clinical significance of serum levels of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in gastric cancer patients. Am J Gastroenterol 98:478–485.

    Article  PubMed  CAS  Google Scholar 

  • Andre F, Rigot V, Thimonier J, Montixi, C, Parat F, Pommier G, Marvaldi J, Luis J (1999) Integrins and E-cadherin cooperate with IGF-I to induce migration of epithelial colonic cells. Int J Cancer 83:497–505.

    Article  PubMed  CAS  Google Scholar 

  • Arboleda MJ, Lyons JF, Kabbinavar FF, Bray MR, Snow BE, Ayala R, Danino M, Karlan BY, Slamon DJ (2003) Overexpression of AKT2/protein kinase BM leads to up-regulation of 1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 63:196–206.

    PubMed  CAS  Google Scholar 

  • Auerbach R (1991) Vascular endothelial cell differentiation: organ-specificity and selective affinities as the basis for developing anti-cancer strategies. Int J Radiat Biol 60:1–10.

    Article  PubMed  CAS  Google Scholar 

  • Balaban NQ, Schwarz US, Riveline D, Goichberg P, Tzur G, Sabanay I, Mahalu D, Safran S, Bershadsky A, Addadi L, Geider B (2001) Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nat Cell Biol 3:466–472.

    Article  PubMed  CAS  Google Scholar 

  • Ballestrem C, Wehrle-Haller B, Hinz B, Imhof BA (2000) Actin-dependent lamellipodia formation and microtubule dependent tail-retraction control directed cell migration. Mol Biol Cell 11:2999–3012.

    PubMed  CAS  Google Scholar 

  • Beningo K, Dembo M, Kaverina I, Small JV, Wang Y (2001) Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J Cell Biol 153:881–888.

    Article  PubMed  CAS  Google Scholar 

  • Ben-Ze’ev A (1994) Colorectal cancer and integrin family of cell adhesion receptors: current status and future directions. Eur J Cancer 30:2166–2170.

    Article  Google Scholar 

  • Bernhard EJ, Gruber SB, Muschel RJ (1994) Direct evidence linking expression of metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci USA 91:4293–4297.

    Article  PubMed  CAS  Google Scholar 

  • Biancone L, Araki M, Araki K, Vassalli P, Stamenkovic I (1996) Redirection of tumor metastasis by expression of E-selectin in vivo. J Exp Med 183:581–587.

    Article  PubMed  CAS  Google Scholar 

  • Bird MI (1997) Selectins: physiological and pathophysiological roles (Review). Biochem Soc Trans 25:1199–1206.

    PubMed  CAS  Google Scholar 

  • Bosman FT, de Bruine A, Flohil C, van der Wurff A, ten Kate J, Dinjens WW (1993) Epithelial–stromal cell interactions in colon cancer. Int J Dev Biol 37:203–211.

    PubMed  CAS  Google Scholar 

  • Bosserhoff AK, Golob M, Buettner R, Landthaler M, Hein R (1997) [MIA (melanoma inhibitory activity). Biological functions and clinical relevance in malignant melanoma]. Hautarzt 49:762–769.

    Article  Google Scholar 

  • Brodt P, Fallavollita L, Bresalier RS, Meterissian S, Norton CR, Wolitzky BA (1997) Liver endothelial E-selectin mediates carcinoma cell adhesion and promotes liver metastasis. Int J Cancer 71:612–619.

    Article  PubMed  CAS  Google Scholar 

  • Byzova TV, Kim W, Midura RJ, Plow EF (2000) Activation of integrin alpha (V) beta (3) regulates cell adhesion and migration to bone sialoprotein. Exp Cell Res 254:229–308.

    Article  CAS  Google Scholar 

  • Carragher NO, Frame MC (2002) Calpain: a role in cell transformation and migration. Int J Biochem Cell Biol 34:1539–1543.

    Article  PubMed  CAS  Google Scholar 

  • Cary LA, Chang, JF, Guan JL (1996) Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J Cell Sci 109:1787–1794.

    PubMed  CAS  Google Scholar 

  • Cary LA, Han DC, Polte TR, Hanks SK, Guan JL (1998) Identification of p130cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol 140:211–221.

    Article  PubMed  CAS  Google Scholar 

  • Crissman JD, Cerra RF, Sarka F (1991) The morphology of cancer cell arrest and extravasation. In: Orr FW, Buchanan MR, Weiss L (eds) Microcirculation and cancer metastasis. CRC, Boca Raton, FL, pp 205–215.

    Google Scholar 

  • Ding LD, Sunamura M, Kodama T, Yamauchi J, Duda DG, Shimamura H, Shibuya K, Takeda K, Matsuno S (2001) In vivo evaluation of the early events associated with liver metastases of circulating cancer cells. Br J Cancer 85:431–438.

    Article  PubMed  CAS  Google Scholar 

  • Dong JT, Suzuki H, Pin SS, Bova GS, Schalken JA, Isaacs WB, Barrett JC, Isaacs JT (1996) Down-regulation of the KAI1 metastases suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss. Cancer Res 56:4387–4390.

    PubMed  CAS  Google Scholar 

  • Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer D, Huang XZ, Sheppard D, Cheresh DA (2002) Src-mediated coupling of focal adhesion kinase to intergin alpha(v) beta5 in vascular endothelial growth factor signaling. J Cell Biol 157:149–160.

    Article  PubMed  CAS  Google Scholar 

  • Entschladen F, Zänker KS (2000) Locomotion of tumor cells: a molecular comparison to migrating pre- and postmitotic leukocytes. J Cancer Clin Oncol 126:671–681.

    Article  CAS  Google Scholar 

  • Ewing J (1928) Neoplastic diseases, 6 edn. W. B. Sanders, Philadelphia, PA.

    Google Scholar 

  • Fenyves AM, Behrens J, Spanel-Borowski K (1993) Cultured microvascular endothelial cells (MVEC) differ in cytoskeleton, expression of cadherins and fibronectin matrix. A study under the influence of interferon-gamma. J Cell Sci 106:879–890.

    PubMed  CAS  Google Scholar 

  • Fidler IJ (1970) Metastasis: quantitative analysis of distribution and fate of tumor emboli labelled with 125 I-5-iodo-2i-deoxyuridine. J Natl Cancer Inst 773–782.

    Google Scholar 

  • Fielding-Habermann B, Habermann R, Saldivar E, Ruggeri ZM (1996) Role of beta3 integrins in melanoma cell adhesion to activated platelets under flow. J Biol Chem 271:5892–5900.

    Article  Google Scholar 

  • Fielding-Habermann B, O’Toole TE, Smith JW Fransvea E, Ruggeri ZM, Ginsberg MH, Hughes PE, Pampori N, Shattil SJ, Saven A, Mueller BM (2001) Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci USA 98:1853–1858.

    Article  Google Scholar 

  • Fincham VJ, Frame MC (1998) The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J 17:81–92.

    Article  PubMed  CAS  Google Scholar 

  • Gangopadhyay A, Lazure DA, Thomas P (1998) Adhesion of colorectal carcinoma cells to the endothelium is mediated by cytokines from CEA stimulated Kupffer cells. Clin Exp Metastasis 16:703–712.

    Article  PubMed  CAS  Google Scholar 

  • Gianelli G, Bergamini C, Fransvea E, Marinosci F, Quaranta V, Antonaci S (2001) Human hepatocellular carcinoma (HCC) cells require both c331 integrin and matrix metalloproteinases activity for migration and invasion. Lab Invest 81:613–627.

    Google Scholar 

  • Glading A, Lauffenburger DA, Wells A (2002) Cutting to the chase: calpain proteases in cell motility. Trends Cell Biol 12:46–54.

    Article  PubMed  CAS  Google Scholar 

  • Glaves D, Huben RP, Weiss L (1988) Haematogenous dissemination of cells from human renal adenocarcinomas. Br J Cancer 57:32–35.

    PubMed  CAS  Google Scholar 

  • Glaves D, Ketch DA, Asch BB (1986) Conservation of epithelial cell phenotypes during haematogenous metastasis from mammary carcinomas. J Natl Cancer Inst 76:933–938.

    PubMed  CAS  Google Scholar 

  • Glinkii OV, Huxley VH, Turk JR, Deutscher SL, Quinn TP, Pienta KJ, Glinsky VV (2003) Continuous real time ex vivo epifluorescent video microscopy for the study of metastatic cancer cell interactions with the microvascular endothelium. Clin Exp Metastasis 20:451–458.

    Article  Google Scholar 

  • Glinsky VV, Glinsky GV, Glinskii OV, Huxley VH, Turk JR, Mossine VV, Deutscher SL, Pienta KJ, Quinn TP (2003) Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. Cancer Res 63:3805–3811.

    PubMed  CAS  Google Scholar 

  • Gong J, Wang D, Sun L, Zborowska E, Willson JK, Brattain MG (1997) Role of G551 in determining malignant properties of colon carcinoma cells. Cell Growth Differ 8:83–90.

    PubMed  CAS  Google Scholar 

  • Guba M, Bosserhoff AK, Steinbauer M, Abels M, Anthuber M, Buettner R, Jauch KW (2000) Overexpression of melanoma inhibitory activity (MIA) enhances extravasation and metastases of A-mel 3 melanoma cells in vivo. Br J Cancer 83:1216–1222.

    Article  PubMed  CAS  Google Scholar 

  • Haier J, Korb T, Hotz B, Spiegel HU, Senninger N (2003) An intravital model to monitor steps of metastatic Tumor cell adhesion within the hepatic microcirculation. J Gastrointest Surg 7:507–514.

    Article  PubMed  Google Scholar 

  • Haier J, Nasralla M, Nicolson GL (1999) Different adhesion properties of highly and poorly metastatic HT-29 carcinoma cells with extracellular matrix components: role of integrin expression and cytoskeletal components. Br J Cancer 80:1867–1874.

    Article  PubMed  CAS  Google Scholar 

  • Haier J, Nasralla M, Nicolson GL (2000) Cell surface molecules and their prognostic values in assessing colorectal carcinomas. Ann Surg 231:11–24.

    Article  PubMed  CAS  Google Scholar 

  • Haier J, Nicolson GL (2001) The role of tumor cell adhesion as an important factor in the formation of distant colorectal metastasis. Dis Colon Rectum 44:876–884.

    Article  PubMed  CAS  Google Scholar 

  • Haier J, Nicolson GL (2001) Tumor cell adhesion adhesion under hydrodynamic conditions of fluid flow. APMIS 109:241–262.

    Article  PubMed  CAS  Google Scholar 

  • Hashida H, Takabayashi A, Tokuhara T, Hattori N, Taki T, Hasegawa H, Satoh S, Kobayashi N, Yamaoka Y, Miyake M (2003) Clinical significance of transmembrane 4 superfamily in colon cancer. Br J Cancer 89:158–167.

    Article  PubMed  CAS  Google Scholar 

  • Hauck CR, Sieg DJ, Hsia DA, Loftus JC, Gaarde WA, Monia BP, Schlaepfer DD (2001) Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells. Cancer Res 61:7079–7090.

    PubMed  CAS  Google Scholar 

  • Hendrix MJ, Seftor EA, Seftor RE, Fidler IJ (1987) A simple quantitative assay for studying the invasive potential of high and low human metastastic variants. Cancer Lett 38:137–147.

    Article  PubMed  CAS  Google Scholar 

  • Hideki U, Koichi H, Yamaguchi KY, Yasoshima T (1998) Separate functions of 9221 and 1331 integrins in the metastatic process of human gastric carcinoma. Surg Today 28:1001–1006.

    Article  Google Scholar 

  • Higashiyama M, Taki T, Ieki Y, Adachi M, Huang C, Koh T, Kodama K, Doi O, Miyake M (1998) Negative motility related protein-1 (MRP-1/CD9) gene expression as a factor of poor prognosis in non-small cell lung cancer. Cancer Res 55:6640–6644.

    Google Scholar 

  • Hoff SD, Matsushita Y, Ota DM, Cleary KR, Yamori T, Hakamori S, Irimura T (1989) Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinomas. Cancer Res 49:6883–6888.

    PubMed  CAS  Google Scholar 

  • Hood JD, Cheresh DA (2002) Role of integrins in cell invasion and migration. Nat Rev Cancer 2:91–100.

    Article  PubMed  Google Scholar 

  • Hsia DA, Mitra SK, Hauck CR, Strebolow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KSR, Cheresh DA, Schlaepfer DD (2003) Differential regulation of cell motility and invasion by FAK. J Cell Biol 160:753–767.

    Article  PubMed  CAS  Google Scholar 

  • Hua J, Muschel RJ (1996) Inhibition of metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system. Cancer Res 56:5279–5284.

    PubMed  CAS  Google Scholar 

  • Huang C, Kohno N, Ogawa E, Adachi M, Taki T, Miyake M (1998) Correlation of reduction in MRP-1/CD9, and KAI1/CD82 with recurrences in breast cancer patients. Am J Pathol 153:973–983.

    PubMed  CAS  Google Scholar 

  • Hynes RO (1987) Integrins: a family of cell surface receptors. Cell 48:549–554.

    Article  PubMed  CAS  Google Scholar 

  • Ikeyama S, Koyama M, Yamaoka M, Sasada R, Miyake M (1993) Suppression of cell motility and metastases by transfection with human motility related protein-1 (/MRP-1/CD9) DNA. J Exp Med 177:1231–1237.

    Article  PubMed  CAS  Google Scholar 

  • Iwai K, Ishikura H, Kaji M, Sugiura H, Ishizu A, Takahashi C, Kato H, Tanabe T, Yoshiki T (1993) Importance of E-selectin (ELAM-1) and sialyl Lewis(a) in the adhesion of pancreatic carcinoma cells to activated endothelium. Int J Cancer 54:972–977.

    Article  PubMed  CAS  Google Scholar 

  • Jackson JG, Zhang X, Yoneda T, Yee D (2001) Regulation of breast cancer cell motility by insulin receptor susbtrate-2 (IRS-2) in metastastic variants of human breast cancer cell lines. Oncogene 20:7318–7325.

    Article  PubMed  CAS  Google Scholar 

  • Kahana O, Micksche M, Witz IP, Yron I (2002) The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanoma. Oncogene 21:3969–3977.

    Article  PubMed  CAS  Google Scholar 

  • Kaverina I, Krylyshkina O, Small JV (1999) Microtubule targeting of substrate contacts promotes their relaxation and dissociation. J Cell Biol 146:1033–1043.

    Article  PubMed  CAS  Google Scholar 

  • Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise LV (1997) Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3) K. Nature 390:632–636.

    Article  PubMed  CAS  Google Scholar 

  • Khatib AM, Kontogianea M, Fallavollita L, Jamison B, Meterissian S, Brodt P (1999) Rapid induction of cytokine and E-selectin expression in the liver in response to metastatic tumor cells. Cancer Res 59:1356–1361.

    PubMed  CAS  Google Scholar 

  • Kirchner J, Kam, Z, Bershadsky AD, Geiger B (2003) Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption. J Cell Sci 116:975–986.

    Article  PubMed  CAS  Google Scholar 

  • Kitakata H, Nemoto-Sasaki Y, Takahashi Y, Kondo T, Mai M, Mukaida N (2002) Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells. Cancer Res 62:6682–6687.

    PubMed  CAS  Google Scholar 

  • Koretz K, Brüderlein S, Henne C, Fietz T, Laque M, Möller P (1994) Comparative evaluation of integrin alpha- and beta-chain expression in colorectal carcinoma cell lines and there tumors. Virchows Arch 425:229–236.

    Article  PubMed  CAS  Google Scholar 

  • Koukoulis GK, Virtanen I, Moll R, Quaranta V, Gould VE (1993) Immunolocalisation of integrins in the normal and neoplastic colonic epithelium. Arch B Cell Pathol Incl Mol Pathol 63:173–184.

    Article  Google Scholar 

  • Lafrenie RM, Gallo S, Podor TJ, Buchanan MR, Orr FW (1994) The relative roles of vitronectin receptor, E-selectin and alpha4-beta1 in cancer cell adhesion to interleukin-1-treated endothelial cells. Eur J Cancer 30A:2151–5158.

    Article  PubMed  CAS  Google Scholar 

  • Liapsi H, Flath A, Kitazawa S (1996) Integrin alpha V beta 3 expression by bone-residing breast cancer metastases. Diagn Mol Pathol 5:127–135.

    Article  Google Scholar 

  • Liddington RC, Bankston LA (2000) The structural basis of dynamic cell adhesion: heads, tails, and allostery. Exp Cell Res 261:37–43.

    Article  PubMed  CAS  Google Scholar 

  • Liotta LA, Kleinermann J, Saidel GM (1974) Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following TC implantation. Cancer Res 34:997–1004.

    PubMed  CAS  Google Scholar 

  • Loftus JC, Liddington RC (1997) New insights into the integrin-ligand interaction. J Clin Invest 100 (Suppl 11):77–81.

    Google Scholar 

  • Lu Z, Jiang G, Blume-Jensen P, Hunter T (2001) Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol 21:4016–4031.

    Article  PubMed  CAS  Google Scholar 

  • Maghazachi AA (2000) Intracellular signaling events at the leading edge of migrating cells. IJBCB 32:931–943.

    CAS  Google Scholar 

  • Max R, Gerritsen RR, Nooijen PT, Goodman SL, Sutter A, Keilholz U, Ruiter DJ, De Waal RM (1997) Immunohistochemical analysis of integrin αvβ3 expression on tumor-associated vessels of human carcinomas. Int J Cancer 71:320–324.

    Article  PubMed  CAS  Google Scholar 

  • Menter DG, Fitzgerald L, Patton JT, McIntire LV, Nicolson GL (1995) Human melanoma integrins contribute to arrest and stabilisation potential while flowing over extracellular matrix. Immunol Cell Biol 73:575–583.

    Article  PubMed  CAS  Google Scholar 

  • Miranti CK, Brugge JS (2002) Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol 4:83–90.

    Article  CAS  Google Scholar 

  • Mizejewski GJ (1999) Role of integrins in cancer: survey of expression patterns. Proc Soc Exp Biol Med 222:124–138.

    Article  PubMed  CAS  Google Scholar 

  • Mook ORF, Marle J, Vreeling-Sindelarova H, Jongens R, Frederiks WM, Noorden CJK (2003) Visualisation of early events in tumor formation of eGFP-transfected rat colon cancer cells in liver. Hepatology 38:295–304.

    Article  PubMed  Google Scholar 

  • Morini M, Mottolese M, Ferrari N, Ghiorzo F, Buglioni S, Mortarini R, Noonan DM, Natali PG, Albini A (2000) The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity. Int J Cancer 87:336–342.

    Article  PubMed  CAS  Google Scholar 

  • Moro L, Dolce L, Cabodi S, Bergatto E, Erba EB, Smeriglio M, Turco E, Retta SF, Giuffrida MG, Venturino M, Godovac-Zimmermann J, Conti A, Schaefer E, Beguinot L, Tacchetti C, Gaggini P, Silengo L, Tarone G, Defilippi P (2002) Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J Biol Chem 277:9405–9414.

    Article  PubMed  CAS  Google Scholar 

  • Müller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner S, Barrera JL, Mohar A, Verastegui E, Zlotnik A (2001) Involvment of chemokine receptors in breast cancer metastases. Nature 410:50–56.

    Article  PubMed  Google Scholar 

  • Nakamori S, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, Sasaki Y, Izumi Y, Irimura T (1997) Involvement of carbohydrate antigene sialyly Lewis(x) in colorectal cancer metastasis. Dis Colon Rectum 40:420–431.

    Article  PubMed  CAS  Google Scholar 

  • Nakashio T, Narita T, Sato M, Akiyama S, Kasai Y, Fujiwara M, Ito K, Takagi H, Kannagi R (1997) The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer. Anticancer Res 17:193–299.

    Google Scholar 

  • Needham LK, Rozengurt E (1998) GN12 and G113 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, Paxilin, and p130 Crk-associated substrate. J Biol Chem 273:14626–14632.

    Article  PubMed  CAS  Google Scholar 

  • Nicolson GL (1988a) Cancer metastasis: TC and host organ properties important in metastasis to specific secondary sites. Biochem Biophys Acta 948:175–224.

    PubMed  CAS  Google Scholar 

  • Nicolson GL (1988b) Differential organ tissue adhesion, invasion, and growth properties of metastatic rat mammary adenocarcinoma cells. Breast Cancer Res Treat 12: 167–176.

    Article  PubMed  CAS  Google Scholar 

  • Nicolson GL (1988c) Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of unique malignant cells at specific organ sites. Cancer Metastasis Rev 7:143–188.

    Article  PubMed  CAS  Google Scholar 

  • Nicolson GL (1989) Metastatic tumor cell interactions with the endothelium, basement membrane and tissue. Curr Opin Cell Biol 1:1009–1019.

    Article  PubMed  CAS  Google Scholar 

  • Nicolson GL, Belloni PN, Tressler RJ, Dulski K, Inoue T, Canaugh PG (1988) Adhesive, invasive, and growth properties of selected metastatic variants of a murine large cell lymphoma. Invasion Metastasis 9:102116.

    Google Scholar 

  • Nicolson GL, Belloni PN, Tressler RJ, Dulski K, Inoune T, Cavanaugh PG (1989) Adhesive, invasive, and growth properties of selected metastatic variants of a murine large-cell lymphoma. Invasion Metastasis 9:102–116.

    PubMed  CAS  Google Scholar 

  • Nip J, Shibata H, Loskutoff DJ, Cheresh DA, Brodt P (1992) Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin. J Clin Invest 90:1406–1413.

    Article  PubMed  CAS  Google Scholar 

  • Nobes CD, Hall A (1995) Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53–62.

    Article  PubMed  CAS  Google Scholar 

  • Numahata K, Satoh M, Handa K, Saito S, Ohyama C, Ito A, Takahashi T, Hoshi S, Orikasa S, Hakamori SI (2002) Sialyl-Le(x) expression defines invasive and metastatic properties of bladder carcinoma. Cancer 94:673–685.

    Article  PubMed  CAS  Google Scholar 

  • Owen JD, Ruest PJ, Fry DW, Hank SK (1999) Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosin phosphorylation of Pyk2. Mol Cell Biol 19:4806–4818.

    PubMed  CAS  Google Scholar 

  • Paget S (1889) The distribution of secondary growth in cancer of the breast. Lancet 1:571–573.

    Article  Google Scholar 

  • Pauli BU, Augustin-Voss HG, el-Sabban ME, Johnson RC, Hammer DA (1990) Organ-preference of metastasis. The role of endothelial cell adhesion molecules. Cancer Metastasis Rev 9:175–189.

    Article  PubMed  CAS  Google Scholar 

  • Renkonen J, Paavonen T, Renkonen R (1997) Endothelial expression of sialyl Lewis(x) and sialyl Lewis(a) in lesions of breast carcinoma. Int J Cancer 74:296–300.

    Article  PubMed  CAS  Google Scholar 

  • Ridley AJ, Hall A (1992) The small GTP-binding protein Rho regulates the assembly of focal adhesion and actin stress fibers in response to growth factors. Cell 70:389–399.

    Article  PubMed  CAS  Google Scholar 

  • Sahai E, Marshall CJ (2003) Differing modes of tumor cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 5:711–719.

    Article  PubMed  CAS  Google Scholar 

  • Sanchez-Madrid F, del Pozo MA (1999) Leukocyte polarisation in cell migration and immune interactions. EMBO 18:501–511.

    Article  CAS  Google Scholar 

  • Sato M, Narita T, Kimura N, Zenita K, Hashimoto T, Manabe T, Kannagi R (1997) The association of sialyl Lewis(a) antigen with the metastastic potential of human colon cancer cells. Anticancer Res 17:3505–3511.

    PubMed  CAS  Google Scholar 

  • Scherbarth S, Orr FW (1997) Intravital videomicroscopic evidence for regulation of metastasis by the hepatic microvasculature: effects of interleukin-1 alpha on metastasis and the location of B16F1 melanoma cell arrest. Cancer Res 57:4105–4110.

    PubMed  CAS  Google Scholar 

  • Schlaepfer DD, Hauck CR, Sieg DJ (1999) Signaling through focal adhesion kinase. Prog Biophys Mol Biol 71:435–478.

    Article  PubMed  CAS  Google Scholar 

  • Scoazec JY, Flejou JF, D’Errico A, Bringuier AF, Fiorentino M, Zamparelli A, Feldmann G, Grigioni WF (1996) Fibrolamellar carcinoma of the liver: composition of the extracellular matrix and expression of cell adhesion molecules. Hepatology 24:1128–1136.

    Article  PubMed  CAS  Google Scholar 

  • Sho M, Adachi M, Taki T, Hashida H, Konishi T, Huang C, Ikeda N, Nakajima Y, Kanehiro H, Hisanga M, Nakano H, Miyake M (1998) Transmembrane 4 superfamily as a prognostic factor in pancreatic cancer. Int J Cancer 79:509–517.

    Article  PubMed  CAS  Google Scholar 

  • Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD (2000) FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 4:249–257.

    Google Scholar 

  • Sieg DJ, Hauck CR, Schlaepfer DD (1999) Requirement role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J Cell Sci 112:2677–2691.

    PubMed  CAS  Google Scholar 

  • Steinbauer M, Guba M, Cernaianu G, Köhl G, Cetto M, Kunz-Schughart LA; Geissler EK, Falk W, Jauch KW (2003) GFP-transfected tumor cells are useful in examining early metastasis in vivo, but immune reaction precludes long-term development studies in immunocompetent mice. Clin Exp Metastasis 20:135–141.

    Article  PubMed  CAS  Google Scholar 

  • Tozeren A, Kleinmann HK, Grant DS, Morales D, Mercurio AM; Byers SW (1995) E-selectin-mediated dynamic interactions of breast cancer cells with endothelial-cell monolayers. Int J Cancer 60:426–431.

    Article  PubMed  CAS  Google Scholar 

  • Trikha M, Zhou Z, Timar J, Raso E, Kennel M, Emmell E, Nakada MT (2002) Multiple Roles for platelet GPIIb/IIIa and Tvv3 integrins in tumor growth, angiogenesis, and metastases. Cancer Res 62:2824–2833.

    PubMed  CAS  Google Scholar 

  • Trusolino L, Bertotti A, Comoglio M (2001) A signaling adaptor function for a664 integrin in the control of HGF-dependent invasive growth. Cell 107:643–654.

    Article  PubMed  CAS  Google Scholar 

  • Volpes R, Van den Oord JJ, Desmet VJ (1993) integrins as differential cell lineage markers of primary liver tumors. Am J Pathol 142:1483–1492.

    PubMed  CAS  Google Scholar 

  • Weis L (1992) Biomechanical interactions of cancer cells within the microvasculature during haematogenous metastases. Cancer Metastasis Rev 11:227–235.

    Article  Google Scholar 

  • Weiss L (1986) Metastatic inefficiency: causes and consequences. Cancer Metastasis Rev 3:1–24.

    Google Scholar 

  • Weiss L, Orr FW, Honn KV (1988) Interactions of cancer cells with the microvasculature during metastasis. FASEB J 2:12–21.

    PubMed  CAS  Google Scholar 

  • Westermarck J, Kähäri VM (1999) Regulation of metalloproteinase expression in tumor invasion. FASEB J 13:781–792.

    PubMed  CAS  Google Scholar 

  • Wolf K, Mazo I, Leung H, Engelke K, von Adrian UH, Deruygina EI, Strongin AY, Brockner EB, Friedl P (2003) Compensation mechanism of tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 160:267–277.

    Article  PubMed  CAS  Google Scholar 

  • Yamada N, Chung YS, Takasuka S, Arimoto Y, Sawada T, Dohi T, Sowa M (1997) Increased sialyl LeA expression and fucosyltransferase activity with acquisition of a high metastatic capacity in a colon cancer cell line. Br J Cancer 76:582–587.

    PubMed  CAS  Google Scholar 

  • Ye C, Kiriyama K, Mistuoka C, Kannagi R, Ito K, Watanabe T, Kondo K, Akiyama S, Takagi H (1995) Expression of E-selectin on endothelial cells of small veins in human colorectal cancer. Int J Cancer 61:455–460.

    Article  PubMed  CAS  Google Scholar 

  • Zeelenberg IS, Ruuls-Van Stalle L, Roos E (2001) Retention of CXCR4 in the endoplasmatic reticulum blocks dissemination of a T-cell hybridoma. J Clin Invest 108:269–277.

    PubMed  CAS  Google Scholar 

  • Zeelenberg IS, Ruuls-Van Stalle L, Roos E (2003) The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res 63:3833–3839.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Molecular Biology Laboratory, Department General Surgery, University Hospital Münster, Germany

    Peter Gassmann & Jörg Haier

  2. Institute for Molecular Medicine, Huntington Beach, CA, USA

    Jörg Haier & Garth L. Nicolson

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  1. Peter Gassmann
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  2. Jörg Haier
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  3. Garth L. Nicolson
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Editor information

Editors and Affiliations

  1. Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, USA

    Hans E. Kaiser

  2. Department of Clinical Pathology, University of Vienna, Austria

    Hans E. Kaiser

  3. Department of Interdisciplinary Oncology-Pathology, Moffit Cancer Center & Research Institute, Tampa, FL, USA

    Aejaz Nasir

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Gassmann, P., Haier, J., Nicolson, G.L. (2008). Cell adhesion and invasion during secondary tumor formation: interactions between tumor cells and host organs. In: Kaiser, H.E., Nasir, A. (eds) Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response. Cancer Growth and Progression, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6729-7_3

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  • DOI: https://doi.org/10.1007/978-1-4020-6729-7_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-6728-0

  • Online ISBN: 978-1-4020-6729-7

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